| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Brian Fuentes | 55.0 | 1 | 5 | 3.93 | 48 | 55 | 46 | 24 | 0.254 |
| Joe Nathan | 68.2 | 2 | 2 | 2.10 | 47 | 52 | 89 | 22 | 0.171 |
| Mariano Rivera | 66.1 | 3 | 3 | 1.76 | 44 | 46 | 72 | 12 | 0.197 |
| Heath Bell | 69.2 | 6 | 4 | 2.71 | 42 | 48 | 79 | 24 | 0.213 |
| Francisco Cordero | 66.2 | 2 | 6 | 2.16 | 39 | 43 | 58 | 30 | 0.243 |
| David Aardsma | 71.1 | 3 | 6 | 2.52 | 38 | 42 | 80 | 34 | 0.190 |
| Brian Wilson | 72.1 | 5 | 6 | 2.74 | 38 | 45 | 83 | 27 | 0.223 |
| Jonathan Papelbon | 68.0 | 1 | 1 | 1.85 | 38 | 41 | 76 | 24 | 0.213 |
| Ryan Franklin | 61.0 | 4 | 3 | 1.92 | 38 | 43 | 44 | 24 | 0.220 |
| Trevor Hoffman | 54.0 | 3 | 2 | 1.83 | 37 | 41 | 48 | 14 | 0.183 |
| Fernando Rodney | 75.2 | 2 | 5 | 4.40 | 37 | 38 | 61 | 41 | 0.249 |
| Jonathan Broxton | 76.0 | 7 | 2 | 2.61 | 36 | 42 | 114 | 29 | 0.165 |
| Huston Street | 61.2 | 4 | 1 | 3.06 | 35 | 37 | 70 | 13 | 0.194 |
| Francisco Rodríguez | 68.0 | 3 | 6 | 3.71 | 35 | 42 | 73 | 38 | 0.203 |
| Brad Lidge | 58.2 | 0 | 8 | 7.21 | 31 | 42 | 61 | 34 | 0.301 |
| Joakim Soria | 53.0 | 3 | 2 | 2.21 | 30 | 33 | 69 | 16 | 0.219 |
| Bobby Jenks | 53.1 | 3 | 4 | 3.71 | 29 | 35 | 49 | 16 | 0.250 |
| Matt Capps | 54.1 | 4 | 8 | 5.80 | 27 | 32 | 46 | 17 | 0.324 |
| Rafael Soriano | 75.2 | 1 | 6 | 2.97 | 27 | 31 | 102 | 27 | 0.194 |
| Leo Núñez | 68.2 | 4 | 6 | 4.06 | 26 | 33 | 60 | 27 | 0.230 |
| Andrew Bailey | 83.1 | 6 | 3 | 1.84 | 26 | 30 | 91 | 24 | 0.167 |
| José Valverde | 54.0 | 4 | 2 | 2.33 | 25 | 29 | 56 | 21 | 0.207 |
| Frank Francisco | 49.1 | 2 | 3 | 3.83 | 25 | 29 | 57 | 15 | 0.214 |
| Chad Qualls | 52.0 | 2 | 2 | 3.63 | 24 | 29 | 45 | 7 | 0.256 |
| Kevin Gregg | 68.2 | 5 | 6 | 4.72 | 23 | 30 | 71 | 30 | 0.229 |
| Mike MacDougal | 50.0 | 1 | 1 | 3.60 | 20 | 21 | 31 | 31 | 0.247 |
| Kerry Wood | 55.0 | 3 | 3 | 4.25 | 20 | 26 | 63 | 28 | 0.233 |
| George Sherrill | 41.1 | 0 | 1 | 2.40 | 20 | 23 | 39 | 13 | 0.219 |
| J.P. Howell | 66.2 | 7 | 5 | 2.84 | 17 | 25 | 79 | 33 | 0.197 |
| Matt Lindstrom | 47.1 | 2 | 1 | 5.89 | 15 | 17 | 39 | 24 | 0.281 |
| Carlos Mármol | 74.0 | 2 | 4 | 3.41 | 15 | 19 | 93 | 65 | 0.170 |
| C.J. Wilson | 73.2 | 5 | 6 | 2.81 | 14 | 18 | 84 | 32 | 0.234 |
| LaTroy Hawkins | 63.1 | 1 | 4 | 2.13 | 11 | 15 | 45 | 16 | 0.253 |
| Jason Frasor | 57.2 | 7 | 3 | 2.50 | 11 | 14 | 56 | 16 | 0.209 |
| Mike González | 74.1 | 5 | 4 | 2.42 | 10 | 17 | 90 | 33 | 0.209 |
| Ryan Madson | 77.1 | 5 | 5 | 3.26 | 10 | 16 | 78 | 22 | 0.251 |
| Jim Johnson | 70.0 | 4 | 6 | 4.11 | 10 | 16 | 49 | 23 | 0.270 |
| Scott Downs | 46.2 | 1 | 3 | 3.09 | 9 | 13 | 43 | 13 | 0.251 |
| Juan Gutiérrez | 71.0 | 4 | 3 | 4.06 | 9 | 10 | 66 | 30 | 0.250 |
| Franklin Morales | 40.0 | 3 | 2 | 4.50 | 7 | 8 | 41 | 23 | 0.250 |
| Brad Ziegler | 73.1 | 2 | 4 | 3.07 | 7 | 10 | 54 | 28 | 0.293 |
| Brandon Morrow | 69.2 | 2 | 4 | 4.39 | 6 | 8 | 63 | 44 | 0.248 |
| Ramon Troncoso | 82.2 | 5 | 4 | 2.72 | 6 | 7 | 55 | 34 | 0.268 |
| Randy Choate | 36.1 | 1 | 0 | 3.47 | 5 | 5 | 28 | 11 | 0.214 |
| Joel Hanrahan | 32.2 | 1 | 3 | 7.71 | 5 | 10 | 35 | 14 | 0.342 |
| Michael Wuertz | 78.2 | 6 | 1 | 2.63 | 4 | 6 | 102 | 23 | 0.188 |
| Matt Thornton | 72.1 | 6 | 3 | 2.74 | 4 | 9 | 87 | 20 | 0.217 |
| Grant Balfour | 67.1 | 5 | 4 | 4.81 | 4 | 9 | 69 | 33 | 0.235 |
| Joe Nelson | 40.1 | 3 | 0 | 4.02 | 3 | 4 | 36 | 27 | 0.213 |
| Phil Hughes | 86.0 | 8 | 3 | 3.03 | 3 | 6 | 96 | 28 | 0.217 |
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