| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Craig Breslow | 55.1 | 7 | 5 | 2.60 | 0 | 2 | 44 | 18 | 0.191 |
| Scott Downs | 46.2 | 1 | 3 | 3.09 | 9 | 13 | 43 | 13 | 0.251 |
| Jesse Crain | 51.2 | 7 | 4 | 4.70 | 0 | 0 | 43 | 27 | 0.250 |
| Ross Detwiler | 75.2 | 1 | 6 | 5.00 | 0 | 0 | 43 | 33 | 0.289 |
| Evan Meek | 47.0 | 1 | 1 | 3.45 | 0 | 1 | 42 | 29 | 0.209 |
| Kyle Farnsworth | 37.1 | 1 | 5 | 4.58 | 0 | 2 | 42 | 14 | 0.287 |
| Scott Olsen | 62.2 | 2 | 4 | 6.03 | 0 | 0 | 42 | 25 | 0.320 |
| R.A. Dickey | 64.1 | 1 | 1 | 4.62 | 0 | 0 | 42 | 30 | 0.290 |
| Franklin Morales | 40.0 | 3 | 2 | 4.50 | 7 | 8 | 41 | 23 | 0.250 |
| John Grabow | 47.1 | 3 | 0 | 3.42 | 0 | 2 | 41 | 28 | 0.246 |
| Shawn Kelley | 46.0 | 5 | 4 | 4.50 | 0 | 4 | 41 | 9 | 0.257 |
| Sergio Romo | 34.0 | 5 | 2 | 3.97 | 2 | 2 | 41 | 11 | 0.233 |
| Jason Bergmann | 48.0 | 2 | 4 | 4.50 | 0 | 1 | 40 | 25 | 0.278 |
| Danys Báez | 71.2 | 4 | 6 | 4.02 | 0 | 2 | 40 | 22 | 0.222 |
| John Smoltz | 38.0 | 1 | 3 | 4.26 | 0 | 0 | 40 | 9 | 0.248 |
| Tom Gorzelanny | 38.1 | 4 | 2 | 5.63 | 0 | 0 | 40 | 13 | 0.262 |
| Seth McClung | 62.0 | 3 | 3 | 4.94 | 0 | 1 | 40 | 39 | 0.267 |
| David Purcey | 48.0 | 1 | 3 | 6.19 | 0 | 0 | 39 | 30 | 0.287 |
| Justin Speier | 40.0 | 4 | 2 | 5.18 | 0 | 1 | 39 | 15 | 0.277 |
| Chris Ray | 43.1 | 0 | 4 | 7.27 | 0 | 3 | 39 | 23 | 0.352 |
| Édgar González | 65.1 | 0 | 4 | 5.51 | 0 | 0 | 39 | 28 | 0.292 |
| George Sherrill | 41.1 | 0 | 1 | 2.40 | 20 | 23 | 39 | 13 | 0.219 |
| Mike Burns | 51.2 | 3 | 5 | 5.75 | 0 | 0 | 39 | 17 | 0.294 |
| Mat Latos | 50.2 | 4 | 5 | 4.62 | 0 | 0 | 39 | 23 | 0.232 |
| Neftali Feliz | 31.0 | 1 | 0 | 1.74 | 2 | 3 | 39 | 8 | 0.124 |
| Chris Tillman | 65.0 | 2 | 5 | 5.40 | 0 | 0 | 39 | 24 | 0.297 |
| Eric O'Flaherty | 56.1 | 2 | 1 | 3.04 | 0 | 2 | 39 | 18 | 0.248 |
| Kevin Hart | 53.1 | 1 | 8 | 6.92 | 0 | 0 | 39 | 26 | 0.333 |
| Guillermo Mota | 65.1 | 3 | 4 | 3.44 | 0 | 2 | 39 | 24 | 0.224 |
| Matt Lindstrom | 47.1 | 2 | 1 | 5.89 | 15 | 17 | 39 | 24 | 0.281 |
| Alberto Arias | 45.2 | 2 | 1 | 3.35 | 0 | 2 | 39 | 19 | 0.272 |
| Brian Matusz | 44.2 | 5 | 2 | 4.63 | 0 | 0 | 38 | 14 | 0.292 |
| Juan Cruz | 50.1 | 3 | 4 | 5.72 | 2 | 6 | 38 | 29 | 0.246 |
| Vicente Padilla | 39.1 | 4 | 0 | 3.20 | 0 | 0 | 38 | 12 | 0.252 |
| Bartolo Colón | 62.1 | 3 | 6 | 4.19 | 0 | 0 | 38 | 21 | 0.280 |
| Chris Pérez | 33.1 | 0 | 1 | 4.32 | 1 | 3 | 38 | 12 | 0.205 |
| Merkin Valdez | 49.1 | 2 | 1 | 5.66 | 0 | 3 | 38 | 28 | 0.292 |
| Ian Snell | 64.1 | 5 | 2 | 4.20 | 0 | 0 | 37 | 39 | 0.247 |
| Freddy García | 56.0 | 3 | 4 | 4.34 | 0 | 0 | 37 | 12 | 0.259 |
| J.D. Martin | 77.0 | 5 | 4 | 4.44 | 0 | 0 | 37 | 24 | 0.279 |
| Pedro Martinez | 44.2 | 5 | 1 | 3.63 | 0 | 0 | 37 | 8 | 0.273 |
| Bobby Seay | 48.2 | 6 | 3 | 4.25 | 0 | 4 | 37 | 17 | 0.253 |
| Joel Hanrahan | 31.1 | 0 | 1 | 1.72 | 0 | 0 | 37 | 20 | 0.204 |
| Justin Miller | 56.2 | 3 | 3 | 3.18 | 0 | 0 | 36 | 27 | 0.236 |
| Lance Cormier | 77.1 | 3 | 3 | 3.26 | 2 | 2 | 36 | 25 | 0.249 |
| Doug Fister | 61.0 | 3 | 4 | 4.13 | 0 | 0 | 36 | 15 | 0.264 |
| Joe Nelson | 40.1 | 3 | 0 | 4.02 | 3 | 4 | 36 | 27 | 0.213 |
| Wade Davis | 36.1 | 2 | 2 | 3.72 | 0 | 0 | 36 | 13 | 0.243 |
| Brian Bruney | 39.0 | 5 | 0 | 3.92 | 0 | 1 | 36 | 23 | 0.243 |
| Santiago Casilla | 48.1 | 1 | 2 | 5.96 | 0 | 0 | 35 | 25 | 0.303 |
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