| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Jamey Wright | 79.0 | 3 | 5 | 4.33 | 0 | 3 | 60 | 44 | 0.247 |
| Pedro Feliciano | 59.1 | 6 | 4 | 3.03 | 0 | 2 | 59 | 18 | 0.231 |
| Andrew Miller | 80.0 | 3 | 5 | 4.84 | 0 | 0 | 59 | 43 | 0.273 |
| Nelson Figueroa | 70.1 | 3 | 8 | 4.09 | 0 | 0 | 59 | 24 | 0.286 |
| Vin Mazzaro | 91.1 | 4 | 9 | 5.32 | 0 | 0 | 59 | 39 | 0.319 |
| Carl Pavano | 73.2 | 5 | 4 | 4.64 | 0 | 0 | 59 | 16 | 0.284 |
| Aaron Laffey | 121.2 | 7 | 9 | 4.44 | 1 | 1 | 59 | 57 | 0.294 |
| Vicente Padilla | 108.0 | 8 | 6 | 4.92 | 0 | 0 | 59 | 42 | 0.286 |
| Renyel Pinto | 61.1 | 4 | 1 | 3.23 | 0 | 4 | 58 | 45 | 0.237 |
| Brandon Medders | 68.2 | 5 | 1 | 3.01 | 1 | 4 | 58 | 32 | 0.248 |
| Francisco Cordero | 66.2 | 2 | 6 | 2.16 | 39 | 43 | 58 | 30 | 0.243 |
| Shawn Camp | 79.2 | 2 | 6 | 3.50 | 1 | 1 | 58 | 29 | 0.245 |
| Tim Byrdak | 61.1 | 1 | 2 | 3.23 | 0 | 2 | 58 | 36 | 0.178 |
| Brandon Lyon | 78.2 | 6 | 5 | 2.86 | 3 | 6 | 57 | 31 | 0.205 |
| Frank Francisco | 49.1 | 2 | 3 | 3.83 | 25 | 29 | 57 | 15 | 0.214 |
| Burke Badenhop | 72.0 | 7 | 4 | 3.75 | 0 | 1 | 57 | 24 | 0.260 |
| Jason Frasor | 57.2 | 7 | 3 | 2.50 | 11 | 14 | 56 | 16 | 0.209 |
| José Valverde | 54.0 | 4 | 2 | 2.33 | 25 | 29 | 56 | 21 | 0.207 |
| Dan Meyer | 58.1 | 3 | 2 | 3.09 | 2 | 2 | 56 | 21 | 0.219 |
| José Mijares | 61.2 | 2 | 2 | 2.34 | 0 | 1 | 55 | 23 | 0.224 |
| Matt Daley | 51.0 | 1 | 1 | 4.24 | 0 | 3 | 55 | 18 | 0.231 |
| Jeremy Affeldt | 62.1 | 2 | 2 | 1.73 | 0 | 0 | 55 | 31 | 0.197 |
| Ramon Troncoso | 82.2 | 5 | 4 | 2.72 | 6 | 7 | 55 | 34 | 0.268 |
| Joe Thatcher | 45.0 | 1 | 0 | 2.80 | 0 | 1 | 55 | 18 | 0.227 |
| Luis Perdomo | 60.0 | 1 | 0 | 4.80 | 0 | 1 | 55 | 34 | 0.246 |
| Scott Linebrink | 56.0 | 3 | 7 | 4.66 | 2 | 4 | 55 | 23 | 0.304 |
| John Maine | 81.1 | 7 | 6 | 4.43 | 0 | 0 | 55 | 38 | 0.224 |
| James McDonald | 63.0 | 5 | 5 | 4.00 | 0 | 0 | 54 | 34 | 0.254 |
| Josh Geer | 102.2 | 1 | 7 | 5.96 | 0 | 0 | 54 | 23 | 0.288 |
| Bud Norris | 55.2 | 6 | 3 | 4.53 | 0 | 0 | 54 | 25 | 0.272 |
| Darren O'Day | 55.2 | 2 | 1 | 1.94 | 2 | 2 | 54 | 17 | 0.188 |
| Brian Bass | 86.1 | 5 | 3 | 4.90 | 0 | 0 | 54 | 44 | 0.306 |
| Brad Ziegler | 73.1 | 2 | 4 | 3.07 | 7 | 10 | 54 | 28 | 0.293 |
| Jason Vargas | 91.2 | 3 | 6 | 4.91 | 0 | 0 | 54 | 24 | 0.281 |
| Dustin Nippert | 69.2 | 5 | 3 | 3.88 | 0 | 0 | 54 | 29 | 0.245 |
| Jason Motte | 56.2 | 4 | 4 | 4.76 | 0 | 3 | 54 | 23 | 0.264 |
| Daisuke Matsuzaka | 59.1 | 4 | 6 | 5.76 | 0 | 0 | 54 | 30 | 0.325 |
| Sean Green | 69.2 | 1 | 4 | 4.52 | 1 | 3 | 54 | 36 | 0.240 |
| Brian Duensing | 84.0 | 5 | 2 | 3.64 | 0 | 0 | 53 | 31 | 0.263 |
| Hideki Okajima | 61.0 | 6 | 0 | 3.39 | 0 | 2 | 53 | 21 | 0.242 |
| Tim Stauffer | 73.0 | 4 | 7 | 3.58 | 0 | 0 | 53 | 34 | 0.259 |
| Josh Outman | 67.1 | 4 | 1 | 3.48 | 0 | 0 | 53 | 25 | 0.212 |
| Justin Masterson | 57.1 | 1 | 7 | 4.55 | 0 | 0 | 52 | 35 | 0.258 |
| Ian Snell | 80.2 | 2 | 8 | 5.36 | 0 | 0 | 52 | 44 | 0.282 |
| Clay Zavada | 51.0 | 3 | 3 | 3.35 | 0 | 0 | 52 | 24 | 0.236 |
| Ramón Ramírez | 69.2 | 7 | 4 | 2.84 | 0 | 4 | 52 | 32 | 0.233 |
| Miguel Batista | 71.1 | 7 | 4 | 4.04 | 1 | 5 | 52 | 39 | 0.282 |
| Jeff Karstens | 108.0 | 4 | 6 | 5.42 | 0 | 0 | 52 | 45 | 0.279 |
| Takashi Saito | 55.2 | 3 | 3 | 2.43 | 2 | 4 | 52 | 25 | 0.244 |
| Ryan Rowland-Smith | 96.1 | 5 | 4 | 3.74 | 0 | 0 | 52 | 27 | 0.239 |
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