| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Jeff Fulchino | 82.0 | 6 | 4 | 3.40 | 0 | 3 | 71 | 27 | 0.233 |
| Sean West | 103.1 | 8 | 6 | 4.79 | 0 | 0 | 70 | 44 | 0.280 |
| Huston Street | 61.2 | 4 | 1 | 3.06 | 35 | 37 | 70 | 13 | 0.194 |
| Nick Masset | 76.0 | 5 | 1 | 2.37 | 0 | 2 | 70 | 24 | 0.203 |
| Mark Lowe | 80.0 | 2 | 7 | 3.26 | 3 | 13 | 69 | 29 | 0.232 |
| Kiko Calero | 60.0 | 2 | 2 | 1.95 | 0 | 5 | 69 | 30 | 0.180 |
| Grant Balfour | 67.1 | 5 | 4 | 4.81 | 4 | 9 | 69 | 33 | 0.235 |
| Matt Palmer | 121.1 | 11 | 2 | 3.93 | 0 | 0 | 69 | 55 | 0.240 |
| Joakim Soria | 53.0 | 3 | 2 | 2.21 | 30 | 33 | 69 | 16 | 0.219 |
| Brett Cecil | 93.1 | 7 | 4 | 5.30 | 0 | 0 | 69 | 38 | 0.308 |
| Alfredo Aceves | 84.0 | 10 | 1 | 3.54 | 1 | 2 | 69 | 16 | 0.220 |
| Clay Buchholz | 92.0 | 7 | 4 | 4.21 | 0 | 0 | 68 | 36 | 0.256 |
| David Hernández | 101.1 | 4 | 10 | 5.42 | 0 | 0 | 68 | 46 | 0.288 |
| Jason Bulger | 65.2 | 6 | 1 | 3.56 | 1 | 4 | 68 | 30 | 0.207 |
| Sean Marshall | 85.1 | 3 | 7 | 4.32 | 0 | 0 | 68 | 32 | 0.274 |
| Micah Owings | 119.2 | 7 | 12 | 5.34 | 1 | 1 | 68 | 64 | 0.272 |
| Justin Masterson | 72.0 | 3 | 3 | 4.50 | 0 | 1 | 67 | 25 | 0.271 |
| Tyler Clippard | 60.1 | 4 | 2 | 2.69 | 0 | 1 | 67 | 32 | 0.172 |
| Clayton Richard | 89.0 | 4 | 3 | 4.65 | 0 | 0 | 66 | 37 | 0.276 |
| Juan Gutiérrez | 71.0 | 4 | 3 | 4.06 | 9 | 10 | 66 | 30 | 0.250 |
| Jason Berken | 119.2 | 6 | 12 | 6.54 | 0 | 0 | 66 | 44 | 0.327 |
| David Huff | 128.1 | 11 | 8 | 5.61 | 0 | 0 | 65 | 41 | 0.301 |
| Brad Bergesen | 123.1 | 7 | 5 | 3.43 | 0 | 0 | 65 | 32 | 0.265 |
| Aaron Heilman | 72.1 | 4 | 4 | 4.11 | 1 | 7 | 65 | 34 | 0.257 |
| Todd Coffey | 83.2 | 4 | 4 | 2.90 | 2 | 6 | 65 | 21 | 0.247 |
| Brandon McCarthy | 97.1 | 7 | 4 | 4.62 | 0 | 0 | 65 | 36 | 0.255 |
| Darren Oliver | 73.0 | 5 | 1 | 2.71 | 0 | 1 | 65 | 22 | 0.237 |
| Russ Ortiz | 85.2 | 3 | 6 | 5.57 | 0 | 0 | 65 | 48 | 0.289 |
| Billy Buckner | 77.1 | 4 | 6 | 6.40 | 0 | 0 | 64 | 29 | 0.306 |
| Ronald Belisario | 70.2 | 4 | 3 | 2.04 | 0 | 7 | 64 | 29 | 0.201 |
| Tommy Hunter | 112.0 | 9 | 6 | 4.10 | 0 | 0 | 64 | 33 | 0.259 |
| Jeff Weaver | 79.0 | 6 | 4 | 3.65 | 0 | 0 | 64 | 33 | 0.281 |
| Brandon Morrow | 69.2 | 2 | 4 | 4.39 | 6 | 8 | 63 | 44 | 0.248 |
| Kerry Wood | 55.0 | 3 | 3 | 4.25 | 20 | 26 | 63 | 28 | 0.233 |
| David Robertson | 43.2 | 2 | 1 | 3.30 | 1 | 1 | 63 | 23 | 0.216 |
| Daniel Bard | 49.1 | 2 | 2 | 3.65 | 1 | 4 | 63 | 22 | 0.228 |
| Chad Durbin | 69.2 | 2 | 2 | 4.39 | 2 | 3 | 62 | 47 | 0.220 |
| Jensen Lewis | 66.1 | 2 | 4 | 4.61 | 1 | 5 | 62 | 29 | 0.249 |
| D.J. Carrasco | 93.1 | 5 | 1 | 3.76 | 0 | 1 | 62 | 29 | 0.281 |
| Charlie Morton | 97.0 | 5 | 9 | 4.55 | 0 | 0 | 62 | 40 | 0.276 |
| Zach Miner | 92.1 | 7 | 5 | 4.29 | 1 | 5 | 62 | 45 | 0.281 |
| Oliver Pérez | 66.0 | 3 | 4 | 6.82 | 0 | 0 | 62 | 58 | 0.273 |
| Fernando Rodney | 75.2 | 2 | 5 | 4.40 | 37 | 38 | 61 | 41 | 0.249 |
| Brad Lidge | 58.2 | 0 | 8 | 7.21 | 31 | 42 | 61 | 34 | 0.301 |
| Mark Hendrickson | 105.0 | 6 | 5 | 4.37 | 1 | 3 | 61 | 33 | 0.280 |
| Peter Moylan | 73.0 | 6 | 2 | 2.84 | 0 | 5 | 61 | 35 | 0.245 |
| Marc Rzepczynski | 61.1 | 2 | 4 | 3.67 | 0 | 0 | 60 | 30 | 0.225 |
| Leo Núñez | 68.2 | 4 | 6 | 4.06 | 26 | 33 | 60 | 27 | 0.230 |
| Ryan Perry | 61.2 | 0 | 1 | 3.79 | 0 | 3 | 60 | 38 | 0.246 |
| Andy Sonnanstine | 99.2 | 6 | 9 | 6.77 | 0 | 0 | 60 | 34 | 0.311 |
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