
| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Erik Bedard | 83.0 | 5 | 3 | 2.82 | 0 | 0 | 90 | 34 | 0.212 |
| Mike González | 74.1 | 5 | 4 | 2.42 | 10 | 17 | 90 | 33 | 0.209 |
| Trevor Cahill | 178.2 | 10 | 13 | 4.63 | 0 | 0 | 90 | 72 | 0.270 |
| José Contreras | 114.2 | 5 | 13 | 5.42 | 0 | 0 | 89 | 45 | 0.267 |
| Joe Nathan | 68.2 | 2 | 2 | 2.10 | 47 | 52 | 89 | 22 | 0.171 |
| John Lannan | 206.1 | 9 | 13 | 3.88 | 0 | 0 | 89 | 68 | 0.266 |
| Rick Porcello | 170.2 | 14 | 9 | 3.96 | 0 | 0 | 89 | 52 | 0.267 |
| Dave Bush | 114.1 | 5 | 9 | 6.38 | 0 | 0 | 89 | 37 | 0.294 |
| Brad Penny | 131.2 | 7 | 8 | 5.61 | 0 | 0 | 89 | 42 | 0.299 |
| Carl Pavano | 125.2 | 9 | 8 | 5.37 | 0 | 0 | 88 | 23 | 0.299 |
| Robinson Tejeda | 73.2 | 4 | 2 | 3.54 | 0 | 0 | 87 | 50 | 0.167 |
| Matt Thornton | 72.1 | 6 | 3 | 2.74 | 4 | 9 | 87 | 20 | 0.217 |
| Hiroki Kuroda | 117.1 | 8 | 7 | 3.76 | 0 | 0 | 87 | 24 | 0.243 |
| Kyle Davies | 123.0 | 8 | 9 | 5.27 | 0 | 0 | 86 | 66 | 0.265 |
| Randy Johnson | 96.0 | 8 | 6 | 4.88 | 0 | 1 | 86 | 31 | 0.262 |
| Homer Bailey | 113.1 | 8 | 5 | 4.53 | 0 | 0 | 86 | 52 | 0.266 |
| C.J. Wilson | 73.2 | 5 | 6 | 2.81 | 14 | 18 | 84 | 32 | 0.234 |
| Jon Garland | 167.2 | 8 | 11 | 4.29 | 0 | 0 | 83 | 52 | 0.286 |
| Brian Wilson | 72.1 | 5 | 6 | 2.74 | 38 | 45 | 83 | 27 | 0.223 |
| Carlos Villanueva | 96.0 | 4 | 10 | 5.34 | 3 | 8 | 83 | 35 | 0.268 |
| Dallas Braden | 136.2 | 8 | 9 | 3.89 | 0 | 0 | 81 | 42 | 0.268 |
| Jeff Suppan | 161.2 | 7 | 12 | 5.29 | 0 | 0 | 80 | 74 | 0.309 |
| David Aardsma | 71.1 | 3 | 6 | 2.52 | 38 | 42 | 80 | 34 | 0.190 |
| Heath Bell | 69.2 | 6 | 4 | 2.71 | 42 | 48 | 79 | 24 | 0.213 |
| J.P. Howell | 66.2 | 7 | 5 | 2.84 | 17 | 25 | 79 | 33 | 0.197 |
| Fausto Carmona | 125.1 | 5 | 12 | 6.32 | 0 | 0 | 79 | 70 | 0.295 |
| Jarrod Washburn | 133.0 | 8 | 6 | 2.64 | 0 | 0 | 79 | 33 | 0.223 |
| Todd Wellemeyer | 122.1 | 7 | 10 | 5.89 | 0 | 0 | 78 | 57 | 0.328 |
| Ryan Madson | 77.1 | 5 | 5 | 3.26 | 10 | 16 | 78 | 22 | 0.251 |
| Aaron Cook | 158.0 | 11 | 6 | 4.16 | 0 | 0 | 78 | 47 | 0.284 |
| Kyle Lohse | 117.2 | 6 | 10 | 4.74 | 0 | 0 | 77 | 36 | 0.269 |
| Edward Mujica | 93.2 | 3 | 5 | 3.94 | 2 | 3 | 76 | 19 | 0.273 |
| Jonathan Papelbon | 68.0 | 1 | 1 | 1.85 | 38 | 41 | 76 | 24 | 0.213 |
| Brandon League | 74.2 | 3 | 6 | 4.58 | 0 | 3 | 76 | 21 | 0.257 |
| Tim Redding | 120.0 | 3 | 6 | 5.10 | 0 | 0 | 76 | 50 | 0.263 |
| Octavio Dotel | 62.1 | 3 | 3 | 3.32 | 0 | 3 | 75 | 36 | 0.239 |
| Kevin Slowey | 90.2 | 10 | 3 | 4.86 | 0 | 0 | 75 | 15 | 0.309 |
| Liván Hernández | 135.0 | 7 | 8 | 5.47 | 0 | 0 | 75 | 51 | 0.312 |
| Yusmeiro Petit | 89.2 | 3 | 10 | 5.82 | 0 | 0 | 74 | 34 | 0.276 |
| Mike Hampton | 112.0 | 7 | 10 | 5.30 | 0 | 0 | 74 | 46 | 0.298 |
| Cliff Lee | 79.2 | 7 | 4 | 3.39 | 0 | 0 | 74 | 10 | 0.261 |
| Bobby Parnell | 88.1 | 4 | 8 | 5.30 | 1 | 5 | 74 | 46 | 0.281 |
| Chan Ho Park | 83.1 | 3 | 3 | 4.43 | 0 | 1 | 73 | 33 | 0.264 |
| Francisco Rodríguez | 68.0 | 3 | 6 | 3.71 | 35 | 42 | 73 | 38 | 0.203 |
| Kris Medlen | 67.2 | 3 | 5 | 4.26 | 0 | 2 | 72 | 30 | 0.256 |
| Garrett Mock | 91.1 | 3 | 10 | 5.62 | 0 | 2 | 72 | 44 | 0.308 |
| Tim Wakefield | 129.2 | 11 | 5 | 4.58 | 0 | 0 | 72 | 50 | 0.270 |
| Mariano Rivera | 66.1 | 3 | 3 | 1.76 | 44 | 46 | 72 | 12 | 0.197 |
| Anibal Sánchez | 86.0 | 4 | 8 | 3.87 | 0 | 0 | 71 | 46 | 0.253 |
| Kevin Gregg | 68.2 | 5 | 6 | 4.72 | 23 | 30 | 71 | 30 | 0.229 |
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