| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Joba Chamberlain | 157.1 | 9 | 6 | 4.75 | 0 | 0 | 133 | 76 | 0.274 |
| Johnny Cueto | 171.1 | 11 | 11 | 4.41 | 0 | 0 | 132 | 61 | 0.262 |
| Bronson Arroyo | 220.1 | 15 | 13 | 3.84 | 0 | 0 | 127 | 65 | 0.256 |
| Jeff Niemann | 180.2 | 13 | 6 | 3.94 | 0 | 0 | 125 | 59 | 0.266 |
| Kevin Millwood | 198.2 | 13 | 10 | 3.67 | 0 | 0 | 123 | 71 | 0.257 |
| Francisco Liriano | 136.2 | 5 | 13 | 5.80 | 0 | 0 | 122 | 65 | 0.279 |
| Brian Tallet | 160.2 | 7 | 9 | 5.32 | 0 | 0 | 120 | 72 | 0.268 |
| J.A. Happ | 166.0 | 12 | 4 | 2.93 | 0 | 0 | 119 | 56 | 0.244 |
| Paul Maholm | 194.2 | 8 | 9 | 4.44 | 0 | 0 | 119 | 60 | 0.290 |
| Scott Richmond | 138.2 | 8 | 11 | 5.52 | 0 | 0 | 117 | 59 | 0.268 |
| Manny Parra | 140.0 | 11 | 11 | 6.36 | 0 | 0 | 116 | 77 | 0.306 |
| Tommy Hanson | 127.2 | 11 | 4 | 2.89 | 0 | 0 | 116 | 46 | 0.225 |
| Jason Marquis | 216.0 | 15 | 13 | 4.04 | 0 | 0 | 115 | 80 | 0.267 |
| Jonathan Broxton | 76.0 | 7 | 2 | 2.61 | 36 | 42 | 114 | 29 | 0.165 |
| Scott Feldman | 189.2 | 17 | 8 | 4.08 | 0 | 0 | 113 | 65 | 0.250 |
| Derek Lowe | 194.2 | 15 | 10 | 4.67 | 0 | 0 | 111 | 63 | 0.301 |
| Jeremy Guthrie | 200.0 | 10 | 17 | 5.04 | 0 | 0 | 110 | 60 | 0.281 |
| Ross Ohlendorf | 176.2 | 11 | 10 | 3.92 | 0 | 0 | 109 | 53 | 0.255 |
| Gio González | 98.2 | 6 | 7 | 5.75 | 0 | 0 | 109 | 56 | 0.288 |
| Cliff Lee | 152.0 | 7 | 9 | 3.14 | 0 | 0 | 107 | 33 | 0.278 |
| Ervin Santana | 139.2 | 8 | 8 | 5.03 | 0 | 0 | 107 | 47 | 0.288 |
| Mike Pelfrey | 184.1 | 10 | 12 | 5.03 | 0 | 0 | 107 | 66 | 0.289 |
| Chris Volstad | 159.0 | 9 | 13 | 5.21 | 0 | 0 | 107 | 59 | 0.278 |
| Derek Holland | 138.1 | 8 | 13 | 6.12 | 0 | 1 | 107 | 47 | 0.288 |
| Zach Duke | 213.0 | 11 | 16 | 4.06 | 0 | 0 | 106 | 49 | 0.285 |
| Luke Hochevar | 143.0 | 7 | 13 | 6.55 | 0 | 0 | 106 | 46 | 0.290 |
| Chad Gaudin | 105.1 | 4 | 10 | 5.13 | 0 | 0 | 105 | 56 | 0.261 |
| Joel Piñeiro | 214.0 | 15 | 12 | 3.49 | 0 | 0 | 105 | 27 | 0.268 |
| Mark Buehrle | 213.1 | 13 | 10 | 3.84 | 0 | 0 | 105 | 45 | 0.275 |
| Kenshin Kawakami | 156.1 | 7 | 12 | 3.86 | 1 | 1 | 105 | 57 | 0.260 |
| Randy Wells | 165.1 | 12 | 10 | 3.05 | 0 | 0 | 104 | 46 | 0.261 |
| David Price | 128.1 | 10 | 7 | 4.42 | 0 | 0 | 102 | 54 | 0.241 |
| Rafael Soriano | 75.2 | 1 | 6 | 2.97 | 27 | 31 | 102 | 27 | 0.194 |
| Michael Wuertz | 78.2 | 6 | 1 | 2.63 | 4 | 6 | 102 | 23 | 0.188 |
| Joe Saunders | 186.0 | 16 | 7 | 4.60 | 0 | 0 | 101 | 64 | 0.279 |
| Braden Looper | 194.2 | 14 | 7 | 5.22 | 0 | 0 | 100 | 64 | 0.289 |
| Brian Bannister | 154.0 | 7 | 12 | 4.73 | 0 | 0 | 98 | 50 | 0.268 |
| Nick Blackburn | 205.2 | 11 | 11 | 4.03 | 0 | 0 | 98 | 41 | 0.290 |
| Phil Hughes | 86.0 | 8 | 3 | 3.03 | 3 | 6 | 96 | 28 | 0.217 |
| Armando Galarraga | 143.2 | 6 | 10 | 5.64 | 0 | 0 | 95 | 67 | 0.284 |
| Gil Meche | 129.0 | 6 | 10 | 5.09 | 0 | 0 | 95 | 58 | 0.281 |
| Jamie Moyer | 162.0 | 12 | 10 | 4.94 | 0 | 0 | 94 | 43 | 0.279 |
| Luke Gregerson | 75.0 | 2 | 4 | 3.24 | 1 | 7 | 93 | 31 | 0.221 |
| Carlos Mármol | 74.0 | 2 | 4 | 3.41 | 15 | 19 | 93 | 65 | 0.170 |
| Felipe Paulino | 97.2 | 3 | 11 | 6.27 | 0 | 1 | 93 | 37 | 0.317 |
| Jake Peavy | 81.2 | 6 | 6 | 3.97 | 0 | 0 | 92 | 28 | 0.228 |
| Jordan Zimmermann | 91.1 | 3 | 5 | 4.63 | 0 | 0 | 92 | 29 | 0.271 |
| Brian Moehler | 154.2 | 8 | 12 | 5.47 | 0 | 0 | 91 | 51 | 0.298 |
| Andrew Bailey | 83.1 | 6 | 3 | 1.84 | 26 | 30 | 91 | 24 | 0.167 |
| Scott Kazmir | 111.0 | 8 | 7 | 5.92 | 0 | 0 | 91 | 50 | 0.273 |
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