| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Jack Taschner | 29.1 | 1 | 1 | 4.91 | 0 | 1 | 19 | 20 | 0.317 |
| Jason Vargas | 91.2 | 3 | 6 | 4.91 | 0 | 0 | 54 | 24 | 0.281 |
| Vicente Padilla | 108.0 | 8 | 6 | 4.92 | 0 | 0 | 59 | 42 | 0.286 |
| Seth McClung | 62.0 | 3 | 3 | 4.94 | 0 | 1 | 40 | 39 | 0.267 |
| Jamie Moyer | 162.0 | 12 | 10 | 4.94 | 0 | 0 | 94 | 43 | 0.279 |
| Joel Zumaya | 31.0 | 3 | 3 | 4.94 | 1 | 7 | 30 | 22 | 0.274 |
| Kevin Jepsen | 54.2 | 6 | 4 | 4.94 | 1 | 2 | 48 | 19 | 0.292 |
| Ross Detwiler | 75.2 | 1 | 6 | 5.00 | 0 | 0 | 43 | 33 | 0.289 |
| Ervin Santana | 139.2 | 8 | 8 | 5.03 | 0 | 0 | 107 | 47 | 0.288 |
| Mike Pelfrey | 184.1 | 10 | 12 | 5.03 | 0 | 0 | 107 | 66 | 0.289 |
| Chris Sampson | 55.1 | 4 | 2 | 5.04 | 3 | 6 | 33 | 21 | 0.293 |
| Jeremy Guthrie | 200.0 | 10 | 17 | 5.04 | 0 | 0 | 110 | 60 | 0.281 |
| Mike Gosling | 25.0 | 0 | 0 | 5.04 | 0 | 0 | 13 | 11 | 0.291 |
| Ricky Nolasco | 185.0 | 13 | 9 | 5.06 | 0 | 0 | 195 | 44 | 0.259 |
| Gil Meche | 129.0 | 6 | 10 | 5.09 | 0 | 0 | 95 | 58 | 0.281 |
| Dennis Sarfate | 23.0 | 0 | 1 | 5.09 | 0 | 0 | 20 | 14 | 0.250 |
| Tim Redding | 120.0 | 3 | 6 | 5.10 | 0 | 0 | 76 | 50 | 0.263 |
| Craig Stammen | 105.2 | 4 | 7 | 5.11 | 0 | 0 | 48 | 24 | 0.271 |
| Chad Gaudin | 105.1 | 4 | 10 | 5.13 | 0 | 0 | 105 | 56 | 0.261 |
| Cristhian Martínez | 26.1 | 1 | 1 | 5.13 | 0 | 1 | 18 | 8 | 0.262 |
| Justin Speier | 40.0 | 4 | 2 | 5.18 | 0 | 1 | 39 | 15 | 0.277 |
| Chris Volstad | 159.0 | 9 | 13 | 5.21 | 0 | 0 | 107 | 59 | 0.278 |
| Chris Young | 76.0 | 4 | 6 | 5.21 | 0 | 0 | 50 | 40 | 0.246 |
| J.J. Putz | 29.1 | 1 | 4 | 5.22 | 2 | 4 | 19 | 19 | 0.257 |
| Braden Looper | 194.2 | 14 | 7 | 5.22 | 0 | 0 | 100 | 64 | 0.289 |
| Brett Tomko | 20.2 | 1 | 2 | 5.23 | 0 | 0 | 11 | 7 | 0.247 |
| Jonathan Albaladejo | 34.1 | 5 | 1 | 5.24 | 0 | 1 | 21 | 16 | 0.306 |
| Jeremy Sowers | 123.1 | 6 | 11 | 5.25 | 0 | 0 | 51 | 52 | 0.281 |
| Shairon Martis | 85.2 | 5 | 3 | 5.25 | 0 | 0 | 34 | 39 | 0.255 |
| Kyle Davies | 123.0 | 8 | 9 | 5.27 | 0 | 0 | 86 | 66 | 0.265 |
| Jeff Suppan | 161.2 | 7 | 12 | 5.29 | 0 | 0 | 80 | 74 | 0.309 |
| Brett Cecil | 93.1 | 7 | 4 | 5.30 | 0 | 0 | 69 | 38 | 0.308 |
| Mike Hampton | 112.0 | 7 | 10 | 5.30 | 0 | 0 | 74 | 46 | 0.298 |
| Bobby Parnell | 88.1 | 4 | 8 | 5.30 | 1 | 5 | 74 | 46 | 0.281 |
| Dan Giese | 22.0 | 0 | 3 | 5.32 | 0 | 0 | 11 | 9 | 0.262 |
| Brian Tallet | 160.2 | 7 | 9 | 5.32 | 0 | 0 | 120 | 72 | 0.268 |
| Chris Jakubauskas | 93.0 | 6 | 7 | 5.32 | 0 | 1 | 47 | 27 | 0.254 |
| Vin Mazzaro | 91.1 | 4 | 9 | 5.32 | 0 | 0 | 59 | 39 | 0.319 |
| Micah Owings | 119.2 | 7 | 12 | 5.34 | 1 | 1 | 68 | 64 | 0.272 |
| Carlos Villanueva | 96.0 | 4 | 10 | 5.34 | 3 | 8 | 83 | 35 | 0.268 |
| Ian Snell | 80.2 | 2 | 8 | 5.36 | 0 | 0 | 52 | 44 | 0.282 |
| Liván Hernández | 48.2 | 2 | 4 | 5.36 | 0 | 0 | 27 | 16 | 0.295 |
| Justin Lehr | 65.1 | 5 | 3 | 5.37 | 0 | 0 | 33 | 28 | 0.286 |
| Carl Pavano | 125.2 | 9 | 8 | 5.37 | 0 | 0 | 88 | 23 | 0.299 |
| Chris Tillman | 65.0 | 2 | 5 | 5.40 | 0 | 0 | 39 | 24 | 0.297 |
| Jeff Karstens | 108.0 | 4 | 6 | 5.42 | 0 | 0 | 52 | 45 | 0.279 |
| José Contreras | 114.2 | 5 | 13 | 5.42 | 0 | 0 | 89 | 45 | 0.267 |
| David Hernández | 101.1 | 4 | 10 | 5.42 | 0 | 0 | 68 | 46 | 0.288 |
| Nate Robertson | 49.2 | 2 | 3 | 5.44 | 0 | 0 | 35 | 28 | 0.295 |
| Wesley Wright | 44.2 | 3 | 4 | 5.44 | 0 | 2 | 47 | 25 | 0.299 |
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