
| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Shawn Kelley | 46.0 | 5 | 4 | 4.50 | 0 | 4 | 41 | 9 | 0.257 |
| Sean Green | 69.2 | 1 | 4 | 4.52 | 1 | 3 | 54 | 36 | 0.240 |
| Bud Norris | 55.2 | 6 | 3 | 4.53 | 0 | 0 | 54 | 25 | 0.272 |
| Manny Delcarmen | 59.2 | 5 | 2 | 4.53 | 0 | 3 | 44 | 34 | 0.270 |
| Homer Bailey | 113.1 | 8 | 5 | 4.53 | 0 | 0 | 86 | 52 | 0.266 |
| Justin Masterson | 57.1 | 1 | 7 | 4.55 | 0 | 0 | 52 | 35 | 0.258 |
| Charlie Morton | 97.0 | 5 | 9 | 4.55 | 0 | 0 | 62 | 40 | 0.276 |
| Brandon League | 74.2 | 3 | 6 | 4.58 | 0 | 3 | 76 | 21 | 0.257 |
| Kyle Farnsworth | 37.1 | 1 | 5 | 4.58 | 0 | 2 | 42 | 14 | 0.287 |
| Tim Wakefield | 129.2 | 11 | 5 | 4.58 | 0 | 0 | 72 | 50 | 0.270 |
| Joe Saunders | 186.0 | 16 | 7 | 4.60 | 0 | 0 | 101 | 64 | 0.279 |
| Jensen Lewis | 66.1 | 2 | 4 | 4.61 | 1 | 5 | 62 | 29 | 0.249 |
| Brandon McCarthy | 97.1 | 7 | 4 | 4.62 | 0 | 0 | 65 | 36 | 0.255 |
| Mat Latos | 50.2 | 4 | 5 | 4.62 | 0 | 0 | 39 | 23 | 0.232 |
| R.A. Dickey | 64.1 | 1 | 1 | 4.62 | 0 | 0 | 42 | 30 | 0.290 |
| Brian Matusz | 44.2 | 5 | 2 | 4.63 | 0 | 0 | 38 | 14 | 0.292 |
| Jordan Zimmermann | 91.1 | 3 | 5 | 4.63 | 0 | 0 | 92 | 29 | 0.271 |
| Trevor Cahill | 178.2 | 10 | 13 | 4.63 | 0 | 0 | 90 | 72 | 0.270 |
| Carl Pavano | 73.2 | 5 | 4 | 4.64 | 0 | 0 | 59 | 16 | 0.284 |
| Clayton Richard | 89.0 | 4 | 3 | 4.65 | 0 | 0 | 66 | 37 | 0.276 |
| Kip Wells | 46.1 | 2 | 3 | 4.66 | 0 | 0 | 25 | 22 | 0.222 |
| Jesse Carlson | 67.2 | 1 | 6 | 4.66 | 0 | 3 | 51 | 21 | 0.258 |
| Scott Linebrink | 56.0 | 3 | 7 | 4.66 | 2 | 4 | 55 | 23 | 0.304 |
| Derek Lowe | 194.2 | 15 | 10 | 4.67 | 0 | 0 | 111 | 63 | 0.301 |
| Jesse Crain | 51.2 | 7 | 4 | 4.70 | 0 | 0 | 43 | 27 | 0.250 |
| Kevin Gregg | 68.2 | 5 | 6 | 4.72 | 23 | 30 | 71 | 30 | 0.229 |
| Brian Bannister | 154.0 | 7 | 12 | 4.73 | 0 | 0 | 98 | 50 | 0.268 |
| Kyle Lohse | 117.2 | 6 | 10 | 4.74 | 0 | 0 | 77 | 36 | 0.269 |
| Joba Chamberlain | 157.1 | 9 | 6 | 4.75 | 0 | 0 | 133 | 76 | 0.274 |
| Jason Motte | 56.2 | 4 | 4 | 4.76 | 0 | 3 | 54 | 23 | 0.264 |
| Leo Rosales | 45.1 | 2 | 1 | 4.76 | 0 | 0 | 31 | 12 | 0.237 |
| Jason Grilli | 26.1 | 2 | 2 | 4.78 | 0 | 0 | 27 | 14 | 0.216 |
| Sean West | 103.1 | 8 | 6 | 4.79 | 0 | 0 | 70 | 44 | 0.280 |
| Ron Mahay | 41.1 | 1 | 1 | 4.79 | 0 | 0 | 34 | 19 | 0.313 |
| Luis Perdomo | 60.0 | 1 | 0 | 4.80 | 0 | 1 | 55 | 34 | 0.246 |
| Grant Balfour | 67.1 | 5 | 4 | 4.81 | 4 | 9 | 69 | 33 | 0.235 |
| Roman Colon | 50.1 | 2 | 3 | 4.83 | 0 | 3 | 29 | 22 | 0.256 |
| Bobby Keppel | 54.0 | 1 | 1 | 4.83 | 0 | 1 | 32 | 21 | 0.297 |
| Jerry Blevins | 22.1 | 0 | 0 | 4.84 | 0 | 0 | 23 | 6 | 0.229 |
| Brad Thompson | 80.0 | 2 | 6 | 4.84 | 0 | 0 | 34 | 23 | 0.273 |
| Brett Myers | 70.2 | 4 | 3 | 4.84 | 0 | 0 | 50 | 23 | 0.272 |
| Andrew Miller | 80.0 | 3 | 5 | 4.84 | 0 | 0 | 59 | 43 | 0.273 |
| Edwin Moreno | 22.1 | 1 | 3 | 4.84 | 0 | 1 | 15 | 15 | 0.311 |
| Kevin Slowey | 90.2 | 10 | 3 | 4.86 | 0 | 0 | 75 | 15 | 0.309 |
| Eric Stults | 50.0 | 4 | 3 | 4.86 | 0 | 0 | 33 | 26 | 0.268 |
| Matt Maloney | 40.2 | 2 | 4 | 4.87 | 0 | 0 | 28 | 8 | 0.281 |
| David Weathers | 24.0 | 1 | 3 | 4.88 | 0 | 1 | 10 | 11 | 0.283 |
| Randy Johnson | 96.0 | 8 | 6 | 4.88 | 0 | 1 | 86 | 31 | 0.262 |
| Julián Tavárez | 35.0 | 3 | 7 | 4.89 | 1 | 2 | 32 | 27 | 0.250 |
| Brian Bass | 86.1 | 5 | 3 | 4.90 | 0 | 0 | 54 | 44 | 0.306 |
| 1 - 2 - 3 - 4 - 5 - 6 - 7 - 8 - 9 - 10 - 11 | |||||||||