| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Jonathon Niese | 25.2 | 1 | 1 | 4.21 | 0 | 0 | 18 | 9 | 0.276 |
| Clay Buchholz | 92.0 | 7 | 4 | 4.21 | 0 | 0 | 68 | 36 | 0.256 |
| Aaron Harang | 162.1 | 6 | 14 | 4.21 | 0 | 0 | 142 | 43 | 0.287 |
| Daniel McCutchen | 36.1 | 1 | 2 | 4.21 | 0 | 0 | 19 | 11 | 0.271 |
| Jonathan Sánchez | 163.1 | 8 | 12 | 4.24 | 0 | 0 | 177 | 88 | 0.221 |
| Matt Daley | 51.0 | 1 | 1 | 4.24 | 0 | 3 | 55 | 18 | 0.231 |
| Tony Peña | 34.0 | 5 | 3 | 4.24 | 1 | 2 | 26 | 11 | 0.295 |
| Bobby Seay | 48.2 | 6 | 3 | 4.25 | 0 | 4 | 37 | 17 | 0.253 |
| Ron Villone | 48.2 | 5 | 6 | 4.25 | 1 | 4 | 33 | 29 | 0.283 |
| Kerry Wood | 55.0 | 3 | 3 | 4.25 | 20 | 26 | 63 | 28 | 0.233 |
| John Smoltz | 38.0 | 1 | 3 | 4.26 | 0 | 0 | 40 | 9 | 0.248 |
| Kris Medlen | 67.2 | 3 | 5 | 4.26 | 0 | 2 | 72 | 30 | 0.256 |
| Jon Garland | 167.2 | 8 | 11 | 4.29 | 0 | 0 | 83 | 52 | 0.286 |
| Zach Miner | 92.1 | 7 | 5 | 4.29 | 1 | 5 | 62 | 45 | 0.281 |
| Rick VandenHurk | 58.2 | 3 | 2 | 4.30 | 0 | 0 | 49 | 21 | 0.252 |
| Ricky Romero | 178.0 | 13 | 9 | 4.30 | 0 | 0 | 141 | 79 | 0.284 |
| Sean Marshall | 85.1 | 3 | 7 | 4.32 | 0 | 0 | 68 | 32 | 0.274 |
| Chris Pérez | 33.1 | 0 | 1 | 4.32 | 1 | 3 | 38 | 12 | 0.205 |
| Cole Hamels | 193.2 | 10 | 11 | 4.32 | 0 | 0 | 168 | 43 | 0.273 |
| Jason Hammel | 176.2 | 10 | 8 | 4.33 | 0 | 0 | 133 | 42 | 0.290 |
| Jamey Wright | 79.0 | 3 | 5 | 4.33 | 0 | 3 | 60 | 44 | 0.247 |
| Manny Acosta | 37.1 | 1 | 1 | 4.34 | 0 | 0 | 32 | 19 | 0.300 |
| Freddy García | 56.0 | 3 | 4 | 4.34 | 0 | 0 | 37 | 12 | 0.259 |
| Edinson Vólquez | 49.2 | 4 | 2 | 4.35 | 0 | 0 | 47 | 32 | 0.191 |
| Scott Baker | 200.0 | 15 | 9 | 4.37 | 0 | 0 | 162 | 48 | 0.247 |
| Mark Hendrickson | 105.0 | 6 | 5 | 4.37 | 1 | 3 | 61 | 33 | 0.280 |
| José Veras | 24.2 | 1 | 2 | 4.38 | 0 | 0 | 22 | 14 | 0.213 |
| Jorge De La Rosa | 185.0 | 16 | 9 | 4.38 | 0 | 0 | 193 | 83 | 0.249 |
| Chad Durbin | 69.2 | 2 | 2 | 4.39 | 2 | 3 | 62 | 47 | 0.220 |
| Brandon Morrow | 69.2 | 2 | 4 | 4.39 | 6 | 8 | 63 | 44 | 0.248 |
| Fernando Rodney | 75.2 | 2 | 5 | 4.40 | 37 | 38 | 61 | 41 | 0.249 |
| Jared Burton | 59.1 | 1 | 0 | 4.40 | 0 | 0 | 45 | 23 | 0.261 |
| Johnny Cueto | 171.1 | 11 | 11 | 4.41 | 0 | 0 | 132 | 61 | 0.262 |
| David Price | 128.1 | 10 | 7 | 4.42 | 0 | 0 | 102 | 54 | 0.241 |
| Esmerling Vásquez | 53.0 | 3 | 3 | 4.42 | 0 | 4 | 45 | 29 | 0.255 |
| Chan Ho Park | 83.1 | 3 | 3 | 4.43 | 0 | 1 | 73 | 33 | 0.264 |
| John Maine | 81.1 | 7 | 6 | 4.43 | 0 | 0 | 55 | 38 | 0.224 |
| Robert Ray | 24.1 | 1 | 2 | 4.44 | 0 | 0 | 13 | 6 | 0.253 |
| J.D. Martin | 77.0 | 5 | 4 | 4.44 | 0 | 0 | 37 | 24 | 0.279 |
| Paul Maholm | 194.2 | 8 | 9 | 4.44 | 0 | 0 | 119 | 60 | 0.290 |
| Aaron Laffey | 121.2 | 7 | 9 | 4.44 | 1 | 1 | 59 | 57 | 0.294 |
| Ryan Sadowski | 28.1 | 2 | 4 | 4.45 | 0 | 0 | 17 | 17 | 0.264 |
| Eddie Guardado | 38.1 | 1 | 2 | 4.46 | 0 | 2 | 20 | 15 | 0.267 |
| Eddie Bonine | 34.1 | 1 | 1 | 4.46 | 0 | 0 | 19 | 12 | 0.308 |
| Carlos Fisher | 52.1 | 1 | 1 | 4.47 | 0 | 1 | 48 | 31 | 0.262 |
| Jason Bergmann | 48.0 | 2 | 4 | 4.50 | 0 | 1 | 40 | 25 | 0.278 |
| Brian Shouse | 28.0 | 1 | 1 | 4.50 | 0 | 1 | 17 | 7 | 0.277 |
| Justin Masterson | 72.0 | 3 | 3 | 4.50 | 0 | 1 | 67 | 25 | 0.271 |
| Franklin Morales | 40.0 | 3 | 2 | 4.50 | 7 | 8 | 41 | 23 | 0.250 |
| Phil Coke | 60.0 | 4 | 3 | 4.50 | 2 | 7 | 49 | 20 | 0.209 |
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