| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Jeff Niemann | 180.2 | 13 | 6 | 3.94 | 0 | 0 | 125 | 59 | 0.266 |
| Edward Mujica | 93.2 | 3 | 5 | 3.94 | 2 | 3 | 76 | 19 | 0.273 |
| Matt Garza | 203.0 | 8 | 12 | 3.95 | 0 | 0 | 189 | 79 | 0.233 |
| Rick Porcello | 170.2 | 14 | 9 | 3.96 | 0 | 0 | 89 | 52 | 0.267 |
| Sergio Romo | 34.0 | 5 | 2 | 3.97 | 2 | 2 | 41 | 11 | 0.233 |
| Jake Peavy | 81.2 | 6 | 6 | 3.97 | 0 | 0 | 92 | 28 | 0.228 |
| Brian Stokes | 70.1 | 2 | 4 | 3.97 | 0 | 2 | 45 | 38 | 0.267 |
| James McDonald | 63.0 | 5 | 5 | 4.00 | 0 | 0 | 54 | 34 | 0.254 |
| Jesse Chavez | 67.1 | 1 | 4 | 4.01 | 0 | 4 | 47 | 22 | 0.264 |
| Joe Nelson | 40.1 | 3 | 0 | 4.02 | 3 | 4 | 36 | 27 | 0.213 |
| Danys Báez | 71.2 | 4 | 6 | 4.02 | 0 | 2 | 40 | 22 | 0.222 |
| Nick Blackburn | 205.2 | 11 | 11 | 4.03 | 0 | 0 | 98 | 41 | 0.290 |
| Chad Billingsley | 196.1 | 12 | 11 | 4.03 | 0 | 0 | 179 | 86 | 0.244 |
| Barry Zito | 192.0 | 10 | 13 | 4.03 | 0 | 0 | 154 | 81 | 0.250 |
| Miguel Batista | 71.1 | 7 | 4 | 4.04 | 1 | 5 | 52 | 39 | 0.282 |
| A.J. Burnett | 207.0 | 13 | 9 | 4.04 | 0 | 0 | 195 | 97 | 0.247 |
| Jason Marquis | 216.0 | 15 | 13 | 4.04 | 0 | 0 | 115 | 80 | 0.267 |
| Joe Blanton | 195.1 | 12 | 8 | 4.05 | 0 | 0 | 163 | 59 | 0.262 |
| Koji Uehara | 66.2 | 2 | 4 | 4.05 | 0 | 0 | 48 | 12 | 0.270 |
| Zach Duke | 213.0 | 11 | 16 | 4.06 | 0 | 0 | 106 | 49 | 0.285 |
| Juan Gutiérrez | 71.0 | 4 | 3 | 4.06 | 9 | 10 | 66 | 30 | 0.250 |
| Gavin Floyd | 193.0 | 11 | 11 | 4.06 | 0 | 0 | 163 | 59 | 0.244 |
| Leo Núñez | 68.2 | 4 | 6 | 4.06 | 26 | 33 | 60 | 27 | 0.230 |
| Brett Anderson | 175.1 | 11 | 11 | 4.06 | 0 | 0 | 150 | 45 | 0.265 |
| Clayton Richard | 64.0 | 5 | 2 | 4.08 | 0 | 0 | 48 | 34 | 0.254 |
| Scott Feldman | 189.2 | 17 | 8 | 4.08 | 0 | 0 | 113 | 65 | 0.250 |
| Rich Harden | 141.0 | 9 | 9 | 4.09 | 0 | 0 | 171 | 67 | 0.234 |
| Nelson Figueroa | 70.1 | 3 | 8 | 4.09 | 0 | 0 | 59 | 24 | 0.286 |
| Russ Springer | 41.2 | 0 | 1 | 4.10 | 0 | 1 | 47 | 14 | 0.299 |
| Tommy Hunter | 112.0 | 9 | 6 | 4.10 | 0 | 0 | 64 | 33 | 0.259 |
| Jim Johnson | 70.0 | 4 | 6 | 4.11 | 10 | 16 | 49 | 23 | 0.270 |
| Chris Smith | 46.0 | 0 | 0 | 4.11 | 0 | 1 | 35 | 19 | 0.232 |
| Aaron Heilman | 72.1 | 4 | 4 | 4.11 | 1 | 7 | 65 | 34 | 0.257 |
| Max Scherzer | 170.1 | 9 | 11 | 4.12 | 0 | 0 | 174 | 63 | 0.253 |
| Pat Misch | 59.0 | 3 | 4 | 4.12 | 0 | 1 | 23 | 19 | 0.278 |
| Doug Davis | 203.1 | 9 | 14 | 4.12 | 0 | 0 | 146 | 103 | 0.267 |
| Roy Oswalt | 181.1 | 8 | 6 | 4.12 | 0 | 0 | 138 | 42 | 0.265 |
| Jason Jennings | 61.0 | 2 | 4 | 4.13 | 1 | 2 | 44 | 28 | 0.286 |
| Doug Fister | 61.0 | 3 | 4 | 4.13 | 0 | 0 | 36 | 15 | 0.264 |
| Jon Rauch | 54.1 | 2 | 2 | 4.14 | 2 | 3 | 35 | 17 | 0.266 |
| Greg Burke | 45.2 | 3 | 3 | 4.14 | 0 | 2 | 33 | 23 | 0.271 |
| James Shields | 219.2 | 11 | 12 | 4.14 | 0 | 0 | 167 | 52 | 0.275 |
| Andy Pettitte | 194.2 | 14 | 8 | 4.16 | 0 | 0 | 148 | 76 | 0.259 |
| Aaron Cook | 158.0 | 11 | 6 | 4.16 | 0 | 0 | 78 | 47 | 0.284 |
| Cla Meredith | 36.2 | 4 | 2 | 4.17 | 0 | 3 | 20 | 13 | 0.324 |
| Chris Pérez | 23.2 | 1 | 1 | 4.18 | 1 | 2 | 30 | 15 | 0.195 |
| Luis Ayala | 32.1 | 1 | 2 | 4.18 | 0 | 3 | 21 | 8 | 0.306 |
| Bartolo Colón | 62.1 | 3 | 6 | 4.19 | 0 | 0 | 38 | 21 | 0.280 |
| Mitchell Boggs | 58.0 | 2 | 3 | 4.19 | 0 | 0 | 46 | 33 | 0.311 |
| Ian Snell | 64.1 | 5 | 2 | 4.20 | 0 | 0 | 37 | 39 | 0.247 |
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