| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Jason Bulger | 65.2 | 6 | 1 | 3.56 | 1 | 4 | 68 | 30 | 0.207 |
| Tim Stauffer | 73.0 | 4 | 7 | 3.58 | 0 | 0 | 53 | 34 | 0.259 |
| Mitch Stetter | 45.0 | 4 | 1 | 3.60 | 1 | 2 | 44 | 27 | 0.216 |
| Mike MacDougal | 50.0 | 1 | 1 | 3.60 | 20 | 21 | 31 | 31 | 0.247 |
| Tim Hudson | 42.1 | 2 | 1 | 3.61 | 0 | 0 | 30 | 13 | 0.295 |
| Edwin Jackson | 214.0 | 13 | 9 | 3.62 | 0 | 0 | 161 | 70 | 0.247 |
| Pedro Martinez | 44.2 | 5 | 1 | 3.63 | 0 | 0 | 37 | 8 | 0.273 |
| Chad Qualls | 52.0 | 2 | 2 | 3.63 | 24 | 29 | 45 | 7 | 0.256 |
| Brian Duensing | 84.0 | 5 | 2 | 3.64 | 0 | 0 | 53 | 31 | 0.263 |
| Ryan Dempster | 200.0 | 11 | 9 | 3.65 | 0 | 0 | 172 | 65 | 0.260 |
| Daniel Bard | 49.1 | 2 | 2 | 3.65 | 1 | 4 | 63 | 22 | 0.228 |
| Jeff Weaver | 79.0 | 6 | 4 | 3.65 | 0 | 0 | 64 | 33 | 0.281 |
| Mark DiFelice | 51.2 | 4 | 1 | 3.66 | 0 | 1 | 48 | 15 | 0.245 |
| Kevin Millwood | 198.2 | 13 | 10 | 3.67 | 0 | 0 | 123 | 71 | 0.257 |
| Marc Rzepczynski | 61.1 | 2 | 4 | 3.67 | 0 | 0 | 60 | 30 | 0.225 |
| Wade LeBlanc | 46.1 | 3 | 1 | 3.69 | 0 | 0 | 30 | 19 | 0.210 |
| Bobby Jenks | 53.1 | 3 | 4 | 3.71 | 29 | 35 | 49 | 16 | 0.250 |
| Francisco Rodríguez | 68.0 | 3 | 6 | 3.71 | 35 | 42 | 73 | 38 | 0.203 |
| Wade Davis | 36.1 | 2 | 2 | 3.72 | 0 | 0 | 36 | 13 | 0.243 |
| Yovani Gallardo | 185.2 | 13 | 12 | 3.73 | 0 | 0 | 204 | 94 | 0.219 |
| Josh Fogg | 45.2 | 0 | 2 | 3.74 | 0 | 0 | 27 | 20 | 0.198 |
| Ryan Rowland-Smith | 96.1 | 5 | 4 | 3.74 | 0 | 0 | 52 | 27 | 0.239 |
| Jered Weaver | 211.0 | 16 | 8 | 3.75 | 0 | 0 | 174 | 66 | 0.246 |
| Burke Badenhop | 72.0 | 7 | 4 | 3.75 | 0 | 1 | 57 | 24 | 0.260 |
| Tony Peña | 36.0 | 1 | 2 | 3.75 | 1 | 2 | 29 | 9 | 0.272 |
| Jeff Gray | 26.1 | 0 | 1 | 3.76 | 0 | 0 | 19 | 4 | 0.278 |
| D.J. Carrasco | 93.1 | 5 | 1 | 3.76 | 0 | 1 | 62 | 29 | 0.281 |
| Hiroki Kuroda | 117.1 | 8 | 7 | 3.76 | 0 | 0 | 87 | 24 | 0.243 |
| Carlos Zambrano | 169.1 | 9 | 7 | 3.77 | 0 | 0 | 152 | 78 | 0.246 |
| Cla Meredith | 28.2 | 0 | 0 | 3.77 | 0 | 0 | 17 | 12 | 0.252 |
| John Danks | 200.1 | 13 | 11 | 3.77 | 0 | 0 | 149 | 73 | 0.245 |
| Ryan Perry | 61.2 | 0 | 1 | 3.79 | 0 | 3 | 60 | 38 | 0.246 |
| Eric Milton | 23.2 | 2 | 1 | 3.80 | 0 | 0 | 20 | 6 | 0.303 |
| John Lackey | 176.1 | 11 | 8 | 3.83 | 0 | 0 | 139 | 47 | 0.263 |
| Frank Francisco | 49.1 | 2 | 3 | 3.83 | 25 | 29 | 57 | 15 | 0.214 |
| Chris Narveson | 47.0 | 2 | 0 | 3.83 | 0 | 0 | 46 | 16 | 0.247 |
| Bronson Arroyo | 220.1 | 15 | 13 | 3.84 | 0 | 0 | 127 | 65 | 0.256 |
| Mark Buehrle | 213.1 | 13 | 10 | 3.84 | 0 | 0 | 105 | 45 | 0.275 |
| Josh Beckett | 212.1 | 17 | 6 | 3.86 | 0 | 0 | 199 | 55 | 0.244 |
| Kenshin Kawakami | 156.1 | 7 | 12 | 3.86 | 1 | 1 | 105 | 57 | 0.260 |
| Ryan Webb | 25.2 | 2 | 1 | 3.86 | 0 | 0 | 19 | 11 | 0.265 |
| Anibal Sánchez | 86.0 | 4 | 8 | 3.87 | 0 | 0 | 71 | 46 | 0.253 |
| Dustin Nippert | 69.2 | 5 | 3 | 3.88 | 0 | 0 | 54 | 29 | 0.245 |
| John Lannan | 206.1 | 9 | 13 | 3.88 | 0 | 0 | 89 | 68 | 0.266 |
| Dallas Braden | 136.2 | 8 | 9 | 3.89 | 0 | 0 | 81 | 42 | 0.268 |
| Kevin Correia | 198.0 | 12 | 11 | 3.91 | 0 | 0 | 142 | 64 | 0.259 |
| Ross Ohlendorf | 176.2 | 11 | 10 | 3.92 | 0 | 0 | 109 | 53 | 0.255 |
| Brian Bruney | 39.0 | 5 | 0 | 3.92 | 0 | 1 | 36 | 23 | 0.243 |
| Matt Palmer | 121.1 | 11 | 2 | 3.93 | 0 | 0 | 69 | 55 | 0.240 |
| Brian Fuentes | 55.0 | 1 | 5 | 3.93 | 48 | 55 | 46 | 24 | 0.254 |
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