| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Steven Jackson | 43.0 | 2 | 3 | 3.14 | 0 | 1 | 21 | 22 | 0.236 |
| Doug Mathis | 42.2 | 0 | 1 | 3.16 | 1 | 1 | 25 | 10 | 0.244 |
| Justin Miller | 56.2 | 3 | 3 | 3.18 | 0 | 0 | 36 | 27 | 0.236 |
| Jeff Bennett | 34.0 | 2 | 4 | 3.18 | 0 | 0 | 23 | 21 | 0.316 |
| Vicente Padilla | 39.1 | 4 | 0 | 3.20 | 0 | 0 | 38 | 12 | 0.252 |
| Sean Burnett | 25.1 | 1 | 1 | 3.20 | 0 | 1 | 20 | 13 | 0.157 |
| Josh Johnson | 209.0 | 15 | 5 | 3.23 | 0 | 0 | 191 | 58 | 0.237 |
| Tim Byrdak | 61.1 | 1 | 2 | 3.23 | 0 | 2 | 58 | 36 | 0.178 |
| Renyel Pinto | 61.1 | 4 | 1 | 3.23 | 0 | 4 | 58 | 45 | 0.237 |
| Randy Wolf | 214.1 | 11 | 7 | 3.23 | 0 | 0 | 160 | 58 | 0.227 |
| Luke Gregerson | 75.0 | 2 | 4 | 3.24 | 1 | 7 | 93 | 31 | 0.221 |
| John Grabow | 25.0 | 0 | 0 | 3.24 | 0 | 0 | 16 | 12 | 0.209 |
| Mark Lowe | 80.0 | 2 | 7 | 3.26 | 3 | 13 | 69 | 29 | 0.232 |
| Lance Cormier | 77.1 | 3 | 3 | 3.26 | 2 | 2 | 36 | 25 | 0.249 |
| Ryan Madson | 77.1 | 5 | 5 | 3.26 | 10 | 16 | 78 | 22 | 0.251 |
| Dan Wheeler | 57.2 | 4 | 5 | 3.28 | 2 | 6 | 45 | 9 | 0.199 |
| Dennys Reyes | 41.0 | 0 | 2 | 3.29 | 1 | 1 | 33 | 21 | 0.233 |
| David Robertson | 43.2 | 2 | 1 | 3.30 | 1 | 1 | 63 | 23 | 0.216 |
| Elmer Dessens | 32.2 | 0 | 0 | 3.31 | 0 | 0 | 14 | 10 | 0.211 |
| David Weathers | 38.0 | 3 | 3 | 3.32 | 1 | 4 | 27 | 17 | 0.199 |
| Octavio Dotel | 62.1 | 3 | 3 | 3.32 | 0 | 3 | 75 | 36 | 0.239 |
| Alberto Arias | 45.2 | 2 | 1 | 3.35 | 0 | 2 | 39 | 19 | 0.272 |
| Clay Zavada | 51.0 | 3 | 3 | 3.35 | 0 | 0 | 52 | 24 | 0.236 |
| CC Sabathia | 230.0 | 19 | 8 | 3.37 | 0 | 0 | 197 | 67 | 0.232 |
| Luke French | 29.1 | 1 | 2 | 3.38 | 0 | 0 | 19 | 11 | 0.275 |
| Kyle McClellan | 66.2 | 4 | 4 | 3.38 | 3 | 6 | 51 | 34 | 0.229 |
| Hideki Okajima | 61.0 | 6 | 0 | 3.39 | 0 | 2 | 53 | 21 | 0.242 |
| Cliff Lee | 79.2 | 7 | 4 | 3.39 | 0 | 0 | 74 | 10 | 0.261 |
| Bob Howry | 63.2 | 2 | 6 | 3.39 | 0 | 3 | 46 | 23 | 0.214 |
| Jeff Fulchino | 82.0 | 6 | 4 | 3.40 | 0 | 3 | 71 | 27 | 0.233 |
| Joe Beimel | 39.2 | 1 | 5 | 3.40 | 1 | 5 | 24 | 15 | 0.253 |
| Carlos Mármol | 74.0 | 2 | 4 | 3.41 | 15 | 19 | 93 | 65 | 0.170 |
| Jon Lester | 203.1 | 15 | 8 | 3.41 | 0 | 0 | 225 | 64 | 0.242 |
| Kyle Kendrick | 26.1 | 3 | 1 | 3.42 | 0 | 0 | 15 | 9 | 0.273 |
| John Grabow | 47.1 | 3 | 0 | 3.42 | 0 | 2 | 41 | 28 | 0.246 |
| Brad Bergesen | 123.1 | 7 | 5 | 3.43 | 0 | 0 | 65 | 32 | 0.265 |
| Chad Gaudin | 42.0 | 2 | 0 | 3.43 | 0 | 0 | 34 | 20 | 0.252 |
| Guillermo Mota | 65.1 | 3 | 4 | 3.44 | 0 | 2 | 39 | 24 | 0.224 |
| Joe Smith | 34.0 | 0 | 0 | 3.44 | 0 | 1 | 30 | 13 | 0.236 |
| Justin Verlander | 240.0 | 19 | 9 | 3.45 | 0 | 0 | 269 | 63 | 0.243 |
| Evan Meek | 47.0 | 1 | 1 | 3.45 | 0 | 1 | 42 | 29 | 0.209 |
| Randy Choate | 36.1 | 1 | 0 | 3.47 | 5 | 5 | 28 | 11 | 0.214 |
| Ubaldo Jiménez | 218.0 | 15 | 12 | 3.47 | 0 | 0 | 198 | 85 | 0.229 |
| Josh Outman | 67.1 | 4 | 1 | 3.48 | 0 | 0 | 53 | 25 | 0.212 |
| Joel Piñeiro | 214.0 | 15 | 12 | 3.49 | 0 | 0 | 105 | 27 | 0.268 |
| Shawn Camp | 79.2 | 2 | 6 | 3.50 | 1 | 1 | 58 | 29 | 0.245 |
| Rafael Betancourt | 30.2 | 1 | 2 | 3.52 | 1 | 3 | 32 | 15 | 0.225 |
| Robinson Tejeda | 73.2 | 4 | 2 | 3.54 | 0 | 0 | 87 | 50 | 0.167 |
| Alfredo Aceves | 84.0 | 10 | 1 | 3.54 | 1 | 2 | 69 | 16 | 0.220 |
| Matt Herges | 25.1 | 2 | 1 | 3.55 | 0 | 1 | 18 | 6 | 0.240 |
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