
| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Blaine Boyer | 37.0 | 0 | 1 | 2.68 | 0 | 0 | 18 | 12 | 0.273 |
| Tyler Clippard | 60.1 | 4 | 2 | 2.69 | 0 | 1 | 67 | 32 | 0.172 |
| Heath Bell | 69.2 | 6 | 4 | 2.71 | 42 | 48 | 79 | 24 | 0.213 |
| Darren Oliver | 73.0 | 5 | 1 | 2.71 | 0 | 1 | 65 | 22 | 0.237 |
| Ramon Troncoso | 82.2 | 5 | 4 | 2.72 | 6 | 7 | 55 | 34 | 0.268 |
| Jon Garland | 36.1 | 3 | 2 | 2.72 | 0 | 0 | 26 | 9 | 0.262 |
| Matt Thornton | 72.1 | 6 | 3 | 2.74 | 4 | 9 | 87 | 20 | 0.217 |
| Brian Wilson | 72.1 | 5 | 6 | 2.74 | 38 | 45 | 83 | 27 | 0.223 |
| Dirk Hayhurst | 22.2 | 0 | 0 | 2.78 | 0 | 0 | 13 | 9 | 0.274 |
| Clayton Kershaw | 171.0 | 8 | 8 | 2.79 | 0 | 0 | 185 | 91 | 0.200 |
| Roy Halladay | 239.0 | 17 | 10 | 2.79 | 0 | 0 | 208 | 35 | 0.256 |
| Sean White | 64.1 | 3 | 2 | 2.80 | 1 | 3 | 28 | 20 | 0.216 |
| Joe Thatcher | 45.0 | 1 | 0 | 2.80 | 0 | 1 | 55 | 18 | 0.227 |
| C.J. Wilson | 73.2 | 5 | 6 | 2.81 | 14 | 18 | 84 | 32 | 0.234 |
| Erik Bedard | 83.0 | 5 | 3 | 2.82 | 0 | 0 | 90 | 34 | 0.212 |
| Tim Wood | 22.1 | 1 | 0 | 2.82 | 0 | 0 | 16 | 10 | 0.272 |
| J.P. Howell | 66.2 | 7 | 5 | 2.84 | 17 | 25 | 79 | 33 | 0.197 |
| Peter Moylan | 73.0 | 6 | 2 | 2.84 | 0 | 5 | 61 | 35 | 0.245 |
| Ramón Ramírez | 69.2 | 7 | 4 | 2.84 | 0 | 4 | 52 | 32 | 0.233 |
| Brandon Lyon | 78.2 | 6 | 5 | 2.86 | 3 | 6 | 57 | 31 | 0.205 |
| Javier Vázquez | 219.1 | 15 | 10 | 2.87 | 0 | 0 | 238 | 44 | 0.223 |
| Tommy Hanson | 127.2 | 11 | 4 | 2.89 | 0 | 0 | 116 | 46 | 0.225 |
| Matt Cain | 217.2 | 14 | 8 | 2.89 | 0 | 0 | 171 | 73 | 0.232 |
| Todd Coffey | 83.2 | 4 | 4 | 2.90 | 2 | 6 | 65 | 21 | 0.247 |
| Tony Sipp | 40.0 | 2 | 0 | 2.93 | 0 | 0 | 48 | 25 | 0.194 |
| J.A. Happ | 166.0 | 12 | 4 | 2.93 | 0 | 0 | 119 | 56 | 0.244 |
| Fernando Nieve | 36.2 | 3 | 3 | 2.95 | 0 | 0 | 23 | 19 | 0.263 |
| Ángel Guzmán | 61.0 | 3 | 3 | 2.95 | 1 | 1 | 47 | 23 | 0.192 |
| Brett Tomko | 36.2 | 4 | 1 | 2.95 | 0 | 0 | 22 | 6 | 0.230 |
| Ken Takahashi | 27.1 | 0 | 1 | 2.96 | 0 | 0 | 23 | 14 | 0.235 |
| Rafael Soriano | 75.2 | 1 | 6 | 2.97 | 27 | 31 | 102 | 27 | 0.194 |
| Hong-Chih Kuo | 30.0 | 2 | 0 | 3.00 | 0 | 1 | 32 | 13 | 0.198 |
| Clay Condrey | 42.0 | 6 | 2 | 3.00 | 1 | 2 | 25 | 14 | 0.233 |
| Brandon Medders | 68.2 | 5 | 1 | 3.01 | 1 | 4 | 58 | 32 | 0.248 |
| Wandy Rodríguez | 205.2 | 14 | 12 | 3.02 | 0 | 0 | 193 | 63 | 0.250 |
| Phil Hughes | 86.0 | 8 | 3 | 3.03 | 3 | 6 | 96 | 28 | 0.217 |
| Pedro Feliciano | 59.1 | 6 | 4 | 3.03 | 0 | 2 | 59 | 18 | 0.231 |
| Eric O'Flaherty | 56.1 | 2 | 1 | 3.04 | 0 | 2 | 39 | 18 | 0.248 |
| Randy Wells | 165.1 | 12 | 10 | 3.05 | 0 | 0 | 104 | 46 | 0.261 |
| Tyler Walker | 35.1 | 2 | 1 | 3.06 | 0 | 0 | 27 | 9 | 0.230 |
| Sean Burnett | 32.1 | 1 | 2 | 3.06 | 1 | 2 | 23 | 15 | 0.200 |
| Huston Street | 61.2 | 4 | 1 | 3.06 | 35 | 37 | 70 | 13 | 0.194 |
| Daniel Ray Herrera | 61.2 | 4 | 4 | 3.06 | 0 | 0 | 44 | 24 | 0.276 |
| Brad Ziegler | 73.1 | 2 | 4 | 3.07 | 7 | 10 | 54 | 28 | 0.293 |
| Dan Meyer | 58.1 | 3 | 2 | 3.09 | 2 | 2 | 56 | 21 | 0.219 |
| Scott Downs | 46.2 | 1 | 3 | 3.09 | 9 | 13 | 43 | 13 | 0.251 |
| Ted Lilly | 177.0 | 12 | 9 | 3.10 | 0 | 0 | 151 | 36 | 0.230 |
| Johan Santana | 166.2 | 13 | 9 | 3.13 | 0 | 0 | 146 | 46 | 0.244 |
| Cliff Lee | 152.0 | 7 | 9 | 3.14 | 0 | 0 | 107 | 33 | 0.278 |
| Dan Haren | 229.1 | 14 | 10 | 3.14 | 0 | 0 | 223 | 38 | 0.224 |
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