| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Matt Harrison | 63.1 | 4 | 5 | 6.11 | 0 | 0 | 34 | 23 | 0.316 |
| Derek Holland | 138.1 | 8 | 13 | 6.12 | 0 | 1 | 107 | 47 | 0.288 |
| David Purcey | 48.0 | 1 | 3 | 6.19 | 0 | 0 | 39 | 30 | 0.287 |
| Joel Peralta | 24.2 | 0 | 3 | 6.20 | 0 | 1 | 22 | 12 | 0.278 |
| Anthony Swarzak | 59.0 | 3 | 7 | 6.25 | 0 | 0 | 34 | 20 | 0.311 |
| Felipe Paulino | 97.2 | 3 | 11 | 6.27 | 0 | 1 | 93 | 37 | 0.317 |
| Fausto Carmona | 125.1 | 5 | 12 | 6.32 | 0 | 0 | 79 | 70 | 0.295 |
| Manny Parra | 140.0 | 11 | 11 | 6.36 | 0 | 0 | 116 | 77 | 0.306 |
| Dave Bush | 114.1 | 5 | 9 | 6.38 | 0 | 0 | 89 | 37 | 0.294 |
| Billy Buckner | 77.1 | 4 | 6 | 6.40 | 0 | 0 | 64 | 29 | 0.306 |
| Jorge Sosa | 22.1 | 2 | 1 | 6.45 | 2 | 2 | 17 | 12 | 0.311 |
| Antonio Bastardo | 23.2 | 2 | 3 | 6.46 | 0 | 0 | 19 | 9 | 0.274 |
| Kip Wells | 26.1 | 0 | 2 | 6.49 | 2 | 2 | 18 | 18 | 0.237 |
| B.J. Ryan | 20.2 | 1 | 1 | 6.53 | 2 | 4 | 13 | 17 | 0.293 |
| Jason Berken | 119.2 | 6 | 12 | 6.54 | 0 | 0 | 66 | 44 | 0.327 |
| Luke Hochevar | 143.0 | 7 | 13 | 6.55 | 0 | 0 | 106 | 46 | 0.290 |
| Anthony Reyes | 38.1 | 1 | 1 | 6.57 | 0 | 0 | 22 | 23 | 0.274 |
| Luke French | 38.0 | 3 | 3 | 6.63 | 0 | 0 | 23 | 17 | 0.344 |
| Andy Sonnanstine | 99.2 | 6 | 9 | 6.77 | 0 | 0 | 60 | 34 | 0.311 |
| Sergio Mitre | 51.2 | 3 | 3 | 6.79 | 0 | 0 | 32 | 13 | 0.321 |
| Oliver Pérez | 66.0 | 3 | 4 | 6.82 | 0 | 0 | 62 | 58 | 0.273 |
| Collin Balester | 30.1 | 1 | 4 | 6.82 | 0 | 0 | 20 | 14 | 0.281 |
| David Patton | 27.2 | 3 | 1 | 6.83 | 0 | 0 | 23 | 19 | 0.279 |
| Kevin Hart | 53.1 | 1 | 8 | 6.92 | 0 | 0 | 39 | 26 | 0.333 |
| Jo-Jo Reyes | 27.0 | 0 | 2 | 7.00 | 0 | 0 | 21 | 13 | 0.262 |
| Kevin Mulvey | 23.0 | 0 | 3 | 7.04 | 0 | 0 | 18 | 12 | 0.264 |
| Scott Schoeneweis | 24.0 | 1 | 2 | 7.13 | 0 | 3 | 14 | 13 | 0.287 |
| Josh Banks | 22.2 | 1 | 1 | 7.15 | 0 | 0 | 9 | 4 | 0.330 |
| Dana Eveland | 44.0 | 2 | 4 | 7.16 | 0 | 0 | 22 | 26 | 0.365 |
| Brad Lidge | 58.2 | 0 | 8 | 7.21 | 31 | 42 | 61 | 34 | 0.301 |
| Chris Ray | 43.1 | 0 | 4 | 7.27 | 0 | 3 | 39 | 23 | 0.352 |
| Rafael Pérez | 48.0 | 4 | 3 | 7.31 | 0 | 1 | 32 | 25 | 0.335 |
| Jarrod Washburn | 43.0 | 1 | 3 | 7.33 | 0 | 0 | 21 | 16 | 0.300 |
| Sidney Ponson | 58.2 | 1 | 7 | 7.36 | 0 | 1 | 32 | 25 | 0.332 |
| Jess Todd | 20.2 | 0 | 1 | 7.40 | 0 | 0 | 18 | 7 | 0.356 |
| Junichi Tazawa | 25.1 | 2 | 3 | 7.46 | 0 | 0 | 13 | 9 | 0.374 |
| Dontrelle Willis | 33.2 | 1 | 4 | 7.49 | 0 | 0 | 17 | 28 | 0.294 |
| Joe Martinez | 30.0 | 3 | 2 | 7.50 | 0 | 0 | 19 | 12 | 0.351 |
| Juan Rincón | 26.1 | 3 | 2 | 7.52 | 0 | 0 | 25 | 20 | 0.191 |
| Jeff Samardzija | 34.2 | 1 | 3 | 7.53 | 0 | 0 | 21 | 15 | 0.329 |
| Joel Hanrahan | 32.2 | 1 | 3 | 7.71 | 5 | 10 | 35 | 14 | 0.342 |
| Hayden Penn | 22.0 | 1 | 0 | 7.77 | 0 | 0 | 27 | 20 | 0.319 |
| Rich Hill | 57.2 | 3 | 3 | 7.80 | 0 | 0 | 46 | 40 | 0.296 |
| Clayton Mortensen | 27.2 | 2 | 4 | 7.81 | 0 | 0 | 11 | 12 | 0.319 |
| Yorman Bazardo | 32.0 | 1 | 3 | 7.88 | 0 | 0 | 17 | 22 | 0.296 |
| Mike Lincoln | 23.0 | 1 | 1 | 8.22 | 0 | 0 | 9 | 19 | 0.326 |
| John Smoltz | 40.0 | 2 | 5 | 8.33 | 0 | 0 | 33 | 9 | 0.343 |
| Kris Benson | 22.1 | 1 | 1 | 8.46 | 0 | 0 | 11 | 12 | 0.340 |
| Adam Eaton | 41.0 | 2 | 5 | 8.56 | 0 | 0 | 28 | 19 | 0.322 |
| Carlos Silva | 30.1 | 1 | 3 | 8.60 | 0 | 0 | 10 | 11 | 0.323 |
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