| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Doug Davis | 203.1 | 9 | 14 | 4.12 | 0 | 0 | 146 | 103 | 0.267 |
| A.J. Burnett | 207.0 | 13 | 9 | 4.04 | 0 | 0 | 195 | 97 | 0.247 |
| Yovani Gallardo | 185.2 | 13 | 12 | 3.73 | 0 | 0 | 204 | 94 | 0.219 |
| Clayton Kershaw | 171.0 | 8 | 8 | 2.79 | 0 | 0 | 185 | 91 | 0.200 |
| Jonathan Sánchez | 163.1 | 8 | 12 | 4.24 | 0 | 0 | 177 | 88 | 0.221 |
| Chad Billingsley | 196.1 | 12 | 11 | 4.03 | 0 | 0 | 179 | 86 | 0.244 |
| Ubaldo Jiménez | 218.0 | 15 | 12 | 3.47 | 0 | 0 | 198 | 85 | 0.229 |
| Jorge De La Rosa | 185.0 | 16 | 9 | 4.38 | 0 | 0 | 193 | 83 | 0.249 |
| Barry Zito | 192.0 | 10 | 13 | 4.03 | 0 | 0 | 154 | 81 | 0.250 |
| Jason Marquis | 216.0 | 15 | 13 | 4.04 | 0 | 0 | 115 | 80 | 0.267 |
| Matt Garza | 203.0 | 8 | 12 | 3.95 | 0 | 0 | 189 | 79 | 0.233 |
| Ricky Romero | 178.0 | 13 | 9 | 4.30 | 0 | 0 | 141 | 79 | 0.284 |
| Carlos Zambrano | 169.1 | 9 | 7 | 3.77 | 0 | 0 | 152 | 78 | 0.246 |
| Manny Parra | 140.0 | 11 | 11 | 6.36 | 0 | 0 | 116 | 77 | 0.306 |
| Andy Pettitte | 194.2 | 14 | 8 | 4.16 | 0 | 0 | 148 | 76 | 0.259 |
| Joba Chamberlain | 157.1 | 9 | 6 | 4.75 | 0 | 0 | 133 | 76 | 0.274 |
| Jair Jurrjens | 215.0 | 14 | 10 | 2.60 | 0 | 0 | 152 | 75 | 0.237 |
| Jeff Suppan | 161.2 | 7 | 12 | 5.29 | 0 | 0 | 80 | 74 | 0.309 |
| John Danks | 200.1 | 13 | 11 | 3.77 | 0 | 0 | 149 | 73 | 0.245 |
| Matt Cain | 217.2 | 14 | 8 | 2.89 | 0 | 0 | 171 | 73 | 0.232 |
| Trevor Cahill | 178.2 | 10 | 13 | 4.63 | 0 | 0 | 90 | 72 | 0.270 |
| Brian Tallet | 160.2 | 7 | 9 | 5.32 | 0 | 0 | 120 | 72 | 0.268 |
| Kevin Millwood | 198.2 | 13 | 10 | 3.67 | 0 | 0 | 123 | 71 | 0.257 |
| Félix Hernández | 238.2 | 19 | 5 | 2.49 | 0 | 0 | 217 | 71 | 0.227 |
| Edwin Jackson | 214.0 | 13 | 9 | 3.62 | 0 | 0 | 161 | 70 | 0.247 |
| Fausto Carmona | 125.1 | 5 | 12 | 6.32 | 0 | 0 | 79 | 70 | 0.295 |
| John Lannan | 206.1 | 9 | 13 | 3.88 | 0 | 0 | 89 | 68 | 0.266 |
| Tim Lincecum | 225.1 | 15 | 7 | 2.48 | 0 | 0 | 261 | 68 | 0.206 |
| Armando Galarraga | 143.2 | 6 | 10 | 5.64 | 0 | 0 | 95 | 67 | 0.284 |
| Rich Harden | 141.0 | 9 | 9 | 4.09 | 0 | 0 | 171 | 67 | 0.234 |
| CC Sabathia | 230.0 | 19 | 8 | 3.37 | 0 | 0 | 197 | 67 | 0.232 |
| Kyle Davies | 123.0 | 8 | 9 | 5.27 | 0 | 0 | 86 | 66 | 0.265 |
| Jered Weaver | 211.0 | 16 | 8 | 3.75 | 0 | 0 | 174 | 66 | 0.246 |
| Adam Wainwright | 233.0 | 19 | 8 | 2.63 | 0 | 0 | 212 | 66 | 0.244 |
| Mike Pelfrey | 184.1 | 10 | 12 | 5.03 | 0 | 0 | 107 | 66 | 0.289 |
| Carlos Mármol | 74.0 | 2 | 4 | 3.41 | 15 | 19 | 93 | 65 | 0.170 |
| Ryan Dempster | 200.0 | 11 | 9 | 3.65 | 0 | 0 | 172 | 65 | 0.260 |
| Bronson Arroyo | 220.1 | 15 | 13 | 3.84 | 0 | 0 | 127 | 65 | 0.256 |
| Francisco Liriano | 136.2 | 5 | 13 | 5.80 | 0 | 0 | 122 | 65 | 0.279 |
| Scott Feldman | 189.2 | 17 | 8 | 4.08 | 0 | 0 | 113 | 65 | 0.250 |
| Jon Lester | 203.1 | 15 | 8 | 3.41 | 0 | 0 | 225 | 64 | 0.242 |
| Joe Saunders | 186.0 | 16 | 7 | 4.60 | 0 | 0 | 101 | 64 | 0.279 |
| Kevin Correia | 198.0 | 12 | 11 | 3.91 | 0 | 0 | 142 | 64 | 0.259 |
| Micah Owings | 119.2 | 7 | 12 | 5.34 | 1 | 1 | 68 | 64 | 0.272 |
| Braden Looper | 194.2 | 14 | 7 | 5.22 | 0 | 0 | 100 | 64 | 0.289 |
| Derek Lowe | 194.2 | 15 | 10 | 4.67 | 0 | 0 | 111 | 63 | 0.301 |
| Justin Verlander | 240.0 | 19 | 9 | 3.45 | 0 | 0 | 269 | 63 | 0.243 |
| Wandy Rodríguez | 205.2 | 14 | 12 | 3.02 | 0 | 0 | 193 | 63 | 0.250 |
| Max Scherzer | 170.1 | 9 | 11 | 4.12 | 0 | 0 | 174 | 63 | 0.253 |
| Johnny Cueto | 171.1 | 11 | 11 | 4.41 | 0 | 0 | 132 | 61 | 0.262 |
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