| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Kyle McClellan | 66.2 | 4 | 4 | 3.38 | 3 | 6 | 51 | 34 | 0.229 |
| Ubaldo Jiménez | 218.0 | 15 | 12 | 3.47 | 0 | 0 | 198 | 85 | 0.229 |
| Kevin Gregg | 68.2 | 5 | 6 | 4.72 | 23 | 30 | 71 | 30 | 0.229 |
| Jerry Blevins | 22.1 | 0 | 0 | 4.84 | 0 | 0 | 23 | 6 | 0.229 |
| Jake Peavy | 81.2 | 6 | 6 | 3.97 | 0 | 0 | 92 | 28 | 0.228 |
| Daniel Bard | 49.1 | 2 | 2 | 3.65 | 1 | 4 | 63 | 22 | 0.228 |
| Randy Wolf | 214.1 | 11 | 7 | 3.23 | 0 | 0 | 160 | 58 | 0.227 |
| Joe Thatcher | 45.0 | 1 | 0 | 2.80 | 0 | 1 | 55 | 18 | 0.227 |
| Félix Hernández | 238.2 | 19 | 5 | 2.49 | 0 | 0 | 217 | 71 | 0.227 |
| Chris Carpenter | 192.2 | 17 | 4 | 2.24 | 0 | 0 | 144 | 38 | 0.226 |
| Tommy Hanson | 127.2 | 11 | 4 | 2.89 | 0 | 0 | 116 | 46 | 0.225 |
| Marc Rzepczynski | 61.1 | 2 | 4 | 3.67 | 0 | 0 | 60 | 30 | 0.225 |
| Rafael Betancourt | 30.2 | 1 | 2 | 3.52 | 1 | 3 | 32 | 15 | 0.225 |
| José Mijares | 61.2 | 2 | 2 | 2.34 | 0 | 1 | 55 | 23 | 0.224 |
| Guillermo Mota | 65.1 | 3 | 4 | 3.44 | 0 | 2 | 39 | 24 | 0.224 |
| John Maine | 81.1 | 7 | 6 | 4.43 | 0 | 0 | 55 | 38 | 0.224 |
| Dan Haren | 229.1 | 14 | 10 | 3.14 | 0 | 0 | 223 | 38 | 0.224 |
| Brian Wilson | 72.1 | 5 | 6 | 2.74 | 38 | 45 | 83 | 27 | 0.223 |
| Javier Vázquez | 219.1 | 15 | 10 | 2.87 | 0 | 0 | 238 | 44 | 0.223 |
| Jarrod Washburn | 133.0 | 8 | 6 | 2.64 | 0 | 0 | 79 | 33 | 0.223 |
| Danys Báez | 71.2 | 4 | 6 | 4.02 | 0 | 2 | 40 | 22 | 0.222 |
| Kip Wells | 46.1 | 2 | 3 | 4.66 | 0 | 0 | 25 | 22 | 0.222 |
| Jonathan Sánchez | 163.1 | 8 | 12 | 4.24 | 0 | 0 | 177 | 88 | 0.221 |
| Luke Gregerson | 75.0 | 2 | 4 | 3.24 | 1 | 7 | 93 | 31 | 0.221 |
| Alfredo Aceves | 84.0 | 10 | 1 | 3.54 | 1 | 2 | 69 | 16 | 0.220 |
| Ryan Franklin | 61.0 | 4 | 3 | 1.92 | 38 | 43 | 44 | 24 | 0.220 |
| Chad Durbin | 69.2 | 2 | 2 | 4.39 | 2 | 3 | 62 | 47 | 0.220 |
| Dan Meyer | 58.1 | 3 | 2 | 3.09 | 2 | 2 | 56 | 21 | 0.219 |
| Yovani Gallardo | 185.2 | 13 | 12 | 3.73 | 0 | 0 | 204 | 94 | 0.219 |
| George Sherrill | 41.1 | 0 | 1 | 2.40 | 20 | 23 | 39 | 13 | 0.219 |
| Joakim Soria | 53.0 | 3 | 2 | 2.21 | 30 | 33 | 69 | 16 | 0.219 |
| Sammy Gervacio | 21.0 | 1 | 1 | 2.14 | 0 | 1 | 25 | 8 | 0.219 |
| Phil Hughes | 86.0 | 8 | 3 | 3.03 | 3 | 6 | 96 | 28 | 0.217 |
| Matt Thornton | 72.1 | 6 | 3 | 2.74 | 4 | 9 | 87 | 20 | 0.217 |
| Mitch Stetter | 45.0 | 4 | 1 | 3.60 | 1 | 2 | 44 | 27 | 0.216 |
| Sean White | 64.1 | 3 | 2 | 2.80 | 1 | 3 | 28 | 20 | 0.216 |
| Jason Grilli | 26.1 | 2 | 2 | 4.78 | 0 | 0 | 27 | 14 | 0.216 |
| David Robertson | 43.2 | 2 | 1 | 3.30 | 1 | 1 | 63 | 23 | 0.216 |
| Randy Choate | 36.1 | 1 | 0 | 3.47 | 5 | 5 | 28 | 11 | 0.214 |
| Bob Howry | 63.2 | 2 | 6 | 3.39 | 0 | 3 | 46 | 23 | 0.214 |
| Frank Francisco | 49.1 | 2 | 3 | 3.83 | 25 | 29 | 57 | 15 | 0.214 |
| Joe Nelson | 40.1 | 3 | 0 | 4.02 | 3 | 4 | 36 | 27 | 0.213 |
| Heath Bell | 69.2 | 6 | 4 | 2.71 | 42 | 48 | 79 | 24 | 0.213 |
| Brent Leach | 20.1 | 2 | 0 | 5.75 | 0 | 0 | 19 | 12 | 0.213 |
| José Veras | 24.2 | 1 | 2 | 4.38 | 0 | 0 | 22 | 14 | 0.213 |
| Jonathan Papelbon | 68.0 | 1 | 1 | 1.85 | 38 | 41 | 76 | 24 | 0.213 |
| Josh Outman | 67.1 | 4 | 1 | 3.48 | 0 | 0 | 53 | 25 | 0.212 |
| Erik Bedard | 83.0 | 5 | 3 | 2.82 | 0 | 0 | 90 | 34 | 0.212 |
| Scott Kazmir | 36.1 | 2 | 2 | 1.73 | 0 | 0 | 26 | 10 | 0.212 |
| Elmer Dessens | 32.2 | 0 | 0 | 3.31 | 0 | 0 | 14 | 10 | 0.211 |
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