| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Carlos Fisher | 52.1 | 1 | 1 | 4.47 | 0 | 1 | 48 | 31 | 0.262 |
| Jon Garland | 36.1 | 3 | 2 | 2.72 | 0 | 0 | 26 | 9 | 0.262 |
| Cristhian Martínez | 26.1 | 1 | 1 | 5.13 | 0 | 1 | 18 | 8 | 0.262 |
| Randy Johnson | 96.0 | 8 | 6 | 4.88 | 0 | 1 | 86 | 31 | 0.262 |
| Joe Blanton | 195.1 | 12 | 8 | 4.05 | 0 | 0 | 163 | 59 | 0.262 |
| Tom Gorzelanny | 38.1 | 4 | 2 | 5.63 | 0 | 0 | 40 | 13 | 0.262 |
| Chad Gaudin | 105.1 | 4 | 10 | 5.13 | 0 | 0 | 105 | 56 | 0.261 |
| Jared Burton | 59.1 | 1 | 0 | 4.40 | 0 | 0 | 45 | 23 | 0.261 |
| Cliff Lee | 79.2 | 7 | 4 | 3.39 | 0 | 0 | 74 | 10 | 0.261 |
| Randy Wells | 165.1 | 12 | 10 | 3.05 | 0 | 0 | 104 | 46 | 0.261 |
| Ryan Dempster | 200.0 | 11 | 9 | 3.65 | 0 | 0 | 172 | 65 | 0.260 |
| Burke Badenhop | 72.0 | 7 | 4 | 3.75 | 0 | 1 | 57 | 24 | 0.260 |
| Kenshin Kawakami | 156.1 | 7 | 12 | 3.86 | 1 | 1 | 105 | 57 | 0.260 |
| Kevin Correia | 198.0 | 12 | 11 | 3.91 | 0 | 0 | 142 | 64 | 0.259 |
| Ricky Nolasco | 185.0 | 13 | 9 | 5.06 | 0 | 0 | 195 | 44 | 0.259 |
| Freddy García | 56.0 | 3 | 4 | 4.34 | 0 | 0 | 37 | 12 | 0.259 |
| Tommy Hunter | 112.0 | 9 | 6 | 4.10 | 0 | 0 | 64 | 33 | 0.259 |
| Andy Pettitte | 194.2 | 14 | 8 | 4.16 | 0 | 0 | 148 | 76 | 0.259 |
| Tim Stauffer | 73.0 | 4 | 7 | 3.58 | 0 | 0 | 53 | 34 | 0.259 |
| Justin Masterson | 57.1 | 1 | 7 | 4.55 | 0 | 0 | 52 | 35 | 0.258 |
| Jesse Carlson | 67.2 | 1 | 6 | 4.66 | 0 | 3 | 51 | 21 | 0.258 |
| Garrett Olson | 80.1 | 3 | 5 | 5.60 | 0 | 0 | 47 | 34 | 0.258 |
| Kevin Millwood | 198.2 | 13 | 10 | 3.67 | 0 | 0 | 123 | 71 | 0.257 |
| Cory Wade | 27.2 | 2 | 3 | 5.53 | 0 | 6 | 18 | 10 | 0.257 |
| Aaron Heilman | 72.1 | 4 | 4 | 4.11 | 1 | 7 | 65 | 34 | 0.257 |
| Brandon League | 74.2 | 3 | 6 | 4.58 | 0 | 3 | 76 | 21 | 0.257 |
| J.J. Putz | 29.1 | 1 | 4 | 5.22 | 2 | 4 | 19 | 19 | 0.257 |
| Shawn Kelley | 46.0 | 5 | 4 | 4.50 | 0 | 4 | 41 | 9 | 0.257 |
| Chad Qualls | 52.0 | 2 | 2 | 3.63 | 24 | 29 | 45 | 7 | 0.256 |
| Roman Colon | 50.1 | 2 | 3 | 4.83 | 0 | 3 | 29 | 22 | 0.256 |
| Bronson Arroyo | 220.1 | 15 | 13 | 3.84 | 0 | 0 | 127 | 65 | 0.256 |
| Clay Buchholz | 92.0 | 7 | 4 | 4.21 | 0 | 0 | 68 | 36 | 0.256 |
| Kris Medlen | 67.2 | 3 | 5 | 4.26 | 0 | 2 | 72 | 30 | 0.256 |
| Roy Halladay | 239.0 | 17 | 10 | 2.79 | 0 | 0 | 208 | 35 | 0.256 |
| Esmerling Vásquez | 53.0 | 3 | 3 | 4.42 | 0 | 4 | 45 | 29 | 0.255 |
| Shairon Martis | 85.2 | 5 | 3 | 5.25 | 0 | 0 | 34 | 39 | 0.255 |
| Brandon McCarthy | 97.1 | 7 | 4 | 4.62 | 0 | 0 | 65 | 36 | 0.255 |
| Ross Ohlendorf | 176.2 | 11 | 10 | 3.92 | 0 | 0 | 109 | 53 | 0.255 |
| Clayton Richard | 64.0 | 5 | 2 | 4.08 | 0 | 0 | 48 | 34 | 0.254 |
| James McDonald | 63.0 | 5 | 5 | 4.00 | 0 | 0 | 54 | 34 | 0.254 |
| Brian Fuentes | 55.0 | 1 | 5 | 3.93 | 48 | 55 | 46 | 24 | 0.254 |
| Chris Jakubauskas | 93.0 | 6 | 7 | 5.32 | 0 | 1 | 47 | 27 | 0.254 |
| Max Scherzer | 170.1 | 9 | 11 | 4.12 | 0 | 0 | 174 | 63 | 0.253 |
| Bobby Seay | 48.2 | 6 | 3 | 4.25 | 0 | 4 | 37 | 17 | 0.253 |
| LaTroy Hawkins | 63.1 | 1 | 4 | 2.13 | 11 | 15 | 45 | 16 | 0.253 |
| Anibal Sánchez | 86.0 | 4 | 8 | 3.87 | 0 | 0 | 71 | 46 | 0.253 |
| Joe Beimel | 39.2 | 1 | 5 | 3.40 | 1 | 5 | 24 | 15 | 0.253 |
| Robert Ray | 24.1 | 1 | 2 | 4.44 | 0 | 0 | 13 | 6 | 0.253 |
| Cla Meredith | 28.2 | 0 | 0 | 3.77 | 0 | 0 | 17 | 12 | 0.252 |
| Vicente Padilla | 39.1 | 4 | 0 | 3.20 | 0 | 0 | 38 | 12 | 0.252 |
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